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兰州大学研究生导师：陈强正文
学习经历
1997－2001 兰州大学生命科学学院生物化学专业 博士
1995－1996 意大利国家野生动物研究所（Istituto Nazionale per la Funa Selvatica）访问学者
1987－1990 兰州大学生物系动物学专业 硕士
1979－1983 兰州大学生物系动物学专业 学士
工作经历
2004- 兰州大学生命科学学院 教授
2004-2010 兰州大学生命科学学院副院长
2006－ 兰州大学生物学实验教学中心（国家级实验教学示范中心）主任
1997-2004 兰州大学生命科学学院 副教授
1990-1997 兰州大学生物系 讲师
1983-1990 兰州大学生物系 助教
教学及指导研究生情况
在读博士研究生3名，硕士研究生9名。已毕业博士研究生5名，硕士研究45名。
发表论文及专著
2015
59. Zhang, Yang, Shiwei Liang, Jianzheng He, Yucheng Bai, Yonggang Niu, Xiaolong Tang, Dongqin Li and Qiang Chen. "Oxidative Stress and Antioxidant Status in a Lizard Phrynocephalus Vlangalii at Different Altitudes or Acclimated to Hypoxia." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 190, (2015): 9-14.
58. Yang, Yongzhi, Lizhong Wang, Jin Han, Xiaolong Tang, Ming Ma, Kun Wang, Xiao Zhang, Qian Ren, Qiang Chen and Qiang Qiu. "Comparative Transcriptomic Analysis Revealed Adaptation Mechanism of Phrynocephalus Erythrurus, the Highest Altitude Lizard Living in the Qinghai-Tibet Plateau." BMC evolutionary biology 15, no. 1 (2015): 101.
57. Xin, Ying, Xiaolong Tang, Huihui Wang, Songsong Lu, Yan Wang, Yang Zhang and Qiang Chen. "Functional Characterization and Expression Analysis of Myoglobin in High-Altitude Lizard Phrynocephalus Erythrurus." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 188, (2015): 31-36.
56. Wang, Cui, Xiaolong Tang, Ying Xin, Feng Yue, Xuefeng Yan, Bingbing Liu, Bei An, Xi Wang and Qiang Chen. "Identification of Sex Chromosomes by Means of Comparative Genomic Hybridization in a Lizard, Eremias Multiocellata." Zoological science 32, no. 2 (2015): 151-156.
55. Lu, Songsong, Ying Xin, Xiaolong Tang, Feng Yue, Huihui Wang, Yucheng Bai, Yonggang Niu and Qiang Chen. "Differences in Hematological Traits between High-and Low-Altitude Lizards (Genus Phrynocephalus)." PloS one 10, no. 5 (2015).
2014
54. Yuan Fang, Shuo Li , Huabin Zhou, Xiaozhu Tian, Shuangyu Lv, Qiang Chen? Opiorphin increases blood pressure of conscious rats through renin-angiotensin system (RAS). Peptides 55 (2014) 47-51
53. XIN, Ying, Huihui WANG, Xiaolong Tang, Songsong LU, Weixin LI, Yang ZHANG, Shiwei LIANG and Qiang CHEN. "Characterisation and Expression Analysis of Sox9 in the Multiocellated Racerunner, Eremias Multiocellata." Asian Herpetological Research 2, (2014): 004.
2013
52. Xiaolong Tang, Ying Xin, Huihui Wang, Weixin Li, Yang Zhang, Shiwei Liang, Jianzheng He, Ningbo Wang, Ming Ma and Qiang Chen*. "Metabolic Characteristics and Response to High Altitude in Phrynocephalus Erythrurus (Lacertilia: Agamidae), a Lizard Dwell at Altitudes Higher Than Any Other Living Lizards in the World." PLoS One, (2013).
51. Xiaolong Tang, F. Yue, J. Z. He, N. B. Wang, M. Ma, J. R. Mo and Q. Chen. "Ontogenetic and Sexual Differences of Thermal Biology and Locomotor Performance in a Lacertid Lizard, Eremias Multiocellata." Zoology (Jena) 116, no. 6 (2013): 331-5.
50. He, J., M. Xiu, Xiaolong Tang, F. Yue, N. Wang, S. Yang and Q. Chen. "The Different Mechanisms of Hypoxic Acclimatization and Adaptation in Lizard Phrynocephalus Vlangalii Living on Qinghai-Tibet Plateau." J Exp Zool A Ecol Genet Physiol 319, no. 3 (2013): 117-23.
49. He, J., M. Xiu, Xiaolong Tang, N. Wang, Y. Xin, W. Li and Q. Chen. "Thermoregulatory and Metabolic Responses to Hypoxia in the Oviparous Lizard, Phrynocephalus Przewalskii." Comp Biochem Physiol A Mol Integr Physiol 165, no. 2 (2013): 207-13.
48. Yang, S., Yang, A., Shao, T., Su, S., Chen, Q.* (2013) Synergistic analgesic effects between neuronostatin and morphine at thesupraspinal level. Peptides 44: 105– 110
47. Lv, S., Yang, Y., Chen, Q.* (2013) Regulation of feeding behavior, gastrointestinal function and fluid homeostasisby apelin. Peptides 44: 87– 92
46. Mo, J., Yang, A., Chen, Z., Shao, T., Zhang, Y., & Chen, Q. (2013). Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. Digestive diseases and sciences, 58(10), 2903-2907.
2012
45. Tang, X., Yue, F., Ma, M., Wang, N., He, J., Chen, Q.* (2012) Effects of Thermal and Hydric Conditions on Egg Incubation and Hatchling Phenotypes in Two Phrynocephalus Lizards. Asian Herpetological Research 3(3): 184-191
44. Tang, X., Yue, F., Zhang, D., Yan, X., Xin, Y., Wang, C., Chen, Q.* (2012) The effect of operational sex ratio on sex allocation and neonate phenotype in a viviparous lizard Eremias multiocellata Amphibia-Reptilia 33: 485-493
43. Su, S., Yang, A., Yang, S., Wang, N., Lu, S., Wang, H., Chen, Q.* (2012) Intracerebroventricular administration of neuronostatin delays gastric emptying and gastrointestinal transit in mice. Peptides 35: 31–35
42. Lv, S., Qin, Y., Wang, H., Xu, N., Yang, Y., Chen, Q.* (2012) Centrally administered apelin-13 induces depression-like behavior in mice. Brain Res Bull 88(6):574-80.
41. Tang, X., Yue, F., Yan, X., Zhang, D., Xin, Y., Wang, C., Chen, Q.* (2012) Effects of gestation temperature on offspring sex and maternal reproduction in aviviparous lizard (Eremias multiocellata) living at high altitude. Journal of Thermal Biology 37: 438–444
40. Yang, S., Yang, A., Su, S., Wang, H., Wang, N., Chen, Q.* (2012) Neuronostatin induces hyperalgesia in formalin test in mice. Neuroscience Letters 506: 126–130
39. Lv, S., Yang, Y., Qin, Y., Mo, J., Wang, N., Wang, Y., Chen, Q.* (2012) Central apelin-13 inhibits food intake via the CRF receptor in mice. Peptides 33: 132-138
38. Yue, F., Tang, X., Zhang, D., Yan, X., Xin, Y., Chen, Q.* (2012) Body temperature and standard metabolic rate of female viviparous lizard Eremias multiocellata during reproduction. Canadian Journal of Zoology 90: 79–84
37. Xin, Y., Tang, X., Yue, F., Zhang, D., Yan, X., Wang, C., Chen, Q.* (2012) Isolation and Sequence Analysis of Sox Genes from lizard Eremias multiocellata. Russian Journal of Genetics 48(1): 88-94
2011
36. Yang, A., Ji, Y., Su, S., Yang, S., Lu, S., Mi, Z., Yang, Q., Chen, Q.* (2011) Intracerebroventricular administration of neuronostatin induces depression-like effect in forced swim test of mice. Peptides 32: 1948–1952
35. Yang, A., Ge, W., Lu, S., Yang, S., Su, S., Mi, Z., Chen, Q.* (2011) Central administration of neuronostatin induces antinociception in mice. Peptides 32: 1893–1901
34. Yan, X., Tang, X., Yue, F., Zhang, D., Xin, Y., Wang, C., Chen, Q.* (2011) Influence of ambient temperature on maternal thermoregulation and neonate phenotypes in a viviparous lizard, Eremias multiocellata, during the gestation period. Journal of Thermal Biology 36: 187–192
33. 吕双瑜 杨爱民 修明慧 杨艳杰 陈强* (2011) 侧脑室注射脂肪酸合成酶抑制剂C75对小鼠学习记忆的影响，中华行为医学与脑科学杂志 20（1）：51-52
32. Lv, S., Yang, Y., Qin, Y., Xiong, X., Chen, Q.* (2011) Effect of centrally administered apelin-13 on gastric emptying and gastrointestinal transit in mice. Peptides 32: 978–982
31. Yang, Q., Lu, S., Tian, X., Yang, A., Ge, W., Chen, Q.* (2011) The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice. Neuroscience Letters 489: 131-135
1993-2010
30. Yang, Y., Lv, S., Xiu, M., Xu, N., Chen, Q.* (2010) Intracerebroventricular administration of apelin-13 inhibits distal colonic transit in mice. Peptides 31: 2241–2246
29. Zhang, D., Yue, F., Tang, X., Chen, Z., Li, R., Chen, Q.* (2010) Effect of gestation temperature on sexual and morphological phenotypes of offsprings in a viviparous lizard, Eremias multiocellata. Journal of Thermal Biology 35: 129–133
28. Tian, X., Chen, J., Xiong, W., He, T., Chen, Q.* (2009) Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides 30:1348-54
27. Xu, N., Wang, H., Fan, L., Chen, Q.* (2009) Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice. Peptides 30: 1153–1157
26. Li, L., Lu, Y., Xiong, W., Liu, J., Chen, Q.* (2008) Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice. European Journal of Pharmacology 595: 90–94
25. Chen, J., Long, Y., Han, H., Wang, T., Chen, Q.,* Wang, R.* (2008) Water-solutable derivates of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacology, Biochemistry and Behavior 90:441-446
24. Zai, K., Hu, L., Chen, J., Fu, C., Chen, Q.* (2008) Chrysin induced hyperalgesia via GABAA receptor in mice. Planta Medica 74:1229-1234
23. 欧阳建梅 陇源 房克难 王锐 陈强*, (2007) 蜂胶乙醇提取物(EEP)对豚鼠胸主动脉的舒张作用, 现代生物医学进展 (9):1286-1289
22. Zhao, Q., Chen, Q., Feng, Y., Lin,X., Wang, R.* (2005) [TIC4] endomorphins, analogues of endomorphins, have significantly nhanced vasorelaxant effects in rat aorta rings. Protein Pept. Lett 12(4), 323-326
21. Xu, P., Chen, Q., Li, H., Yu, Y., Yan, X., Wang, R.* (2005) The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie 60 375-377
20. Feng, Y., Zhao, Q., Chen, Q., Wang, R.* (2005) Vasorelaxant responses to endomorphin1[ ], analogues of endomorphins, in rat aorta rings.Yand endomorphine2[ pharmazie 60:851-855
19. Fu, C., Kong, Z., Wang, K., Yang, Q., Zhai, K., Chen, Q.,* Wang, R.* (2005) Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Research 1056, 51-58
18. Zhao, Q., Chen, Q., Yang, D., Feng, Y., Long, Y., Wang, P., Wang, R.* (2005) Endomorphin 1[c] and endomorphin 2[c], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception. Life Sci., 77, 1155-1165
17. Xu, P., Chang, M., Chen, L., Chen, Q.,* Yan, X.,* Wang, R.* (2004) The relaxant Effect of nociceptin on porcine coronary arterial ring segment. Can. J. Physiol. Pharmacol 82, 993-999
16. Lin, X., Chen, Q., Xue, L., Ma, X., Wang, R.* (2004) Endomorphins, endogenous opioid peptides induce apoptosis in human leukemia HL-60 cells. Can. J. Physiol. Pharmacol 82, 1018-1025
15. Chen, L., Fang, Q., Chen, Q.,* Guo, J., Wang, Z., Chen, Y., Wang, R. * (2004) Study in vitro and in vivo of nociceptin/orphanin FQ(1–13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3. Peptides 25, 1349-1354
14. Lin, X., Cai, Y., Li, Z., Chen, Q., Wang, R.*(2003) Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata. Biochim. Biophys. Acta 1622: 99
13. Lin, X., Yang, D., Cai, W., Zhao, Q., Gao, Y., Chen, Q., Wang, R.* (2003) Endomorphins, endogenous opioid peptide, provide antioxidant defense in the brain against free radicall-induced damage. Biochim. Biophys. Acta (BBA)-Mol. Basis. Dis 1639: 195
12. Chen, Q., Chen, Y., Chen, L., Yang, D., Dong, S., Wang, R.* (2001) The effects of the synthetic nocistation on blood vessel activities. Chin. Sci. Bull 46(8): 275
11. 吴宁, 霍笑风, 陈强, 杨顶建, 王 锐* (2001) 侧脑室注射内吗啡肽-1对麻醉大鼠血压的影响. 药学学报 36(10): 731"
10. 吴宁, 任维华, 霍笑风, 陈强, 王 锐* (2001) 内吗啡肽及其类似物对心血管系统的作用. 药学学报 36(4): 241
9. 陈勇, 陈鲤翔, 陈强, 杨顶建, 彭雅丽, 杨祺, 王 锐* (2001) 痛稳素碳末端八肽翻转孤啡肽对抗吗啡镇痛的作用. 中国药理学通报17(4): 383
8. Chen, Q., Chen, L., Chen, Y., Yang, D., Peng, Y., Dong, S., Wang, R.* (2000) Effects of the synthesized nocistatin and nocistatin (10-17) on analgesia induced by endomorphin-1 and endomorphin-2. Acta Pharmacol. Sin 21(11): 1053"
7. 陈强, 陈勇, 陈鲤翔, 杨顶建, 董守良, 王 锐* (2000) 痛稳素的合成及其对血管活性的影响. 科学通报 45(24): 2620）
6. Chen, Q., Chang, C., Liu, N., E. Randi, V. Licchini, Mitochondrial DNA intro-gression between two parapatric species (Alectoris) in Central China动物学报1999,45(4):456
5. 陈强, 李仁德, 刘迺发, (1999) 雄性密点麻蜥精巢支持细胞和间质细胞的年周期变化. 兰州大学学报 35(专辑)80-82
4. Li, R., Chen, Qiang., Liu, N. (1998) Effects of body temperature on electrocardiograms of lizard Eremias multiocellata. 动物学研究 19(4): 269-276
3. 李仁德, 陈强, 刘迺发, (1996) 温度对蜥蜴血红蛋白及血浆总蛋白浓度的影响, 动物学报, 42(3):247-252
2. 陈强, (1995) 丽斑麻蜥和草原沙蜥静止代谢率的研究, 兰州大学学报(自然科学版), 31(1):68-71
1. 陈强, 韩昭雪, (1993) 变色沙蜥繁殖的研究, 兰州大学学报(自然科学版) 29(4):199- 204
研究方向
蜥蜴对干旱、高寒、缺氧等环境的适应机制
肽类激素或其它多肽的生物学活性与作用机理
项目成果
密点麻蜥性别决定机制的研究 国家自然科学基金面上项目，2007.1-2009.12，（主持）
三种沙蜥的性别决定机制以及孵化温度对其幼体生存能力影响的研究 国家自然科学基金面上项目，2011.1－2011.12（主持）
若干多肽合成和化学修饰的新方法和关键技术及其在多肽药物产业开发中的应用 国家科技重大专项 2009.1-2010.12（参加）
青海沙蜥和红尾沙蜥对高原低氧的适应机制研究 国家自然科学基金面上项目，2013－2016（主持）
红尾沙蜥适应和耐受低温的机制 国家自然科学基金面上项目，2015-2018（主持）
荣誉、获奖
兰州大学第四届“我最喜爱的十大教师”
兰州大学2009年教书育人先进个人
甘肃省高等学校实验室建设与管理先进工作者 2006
甘肃省教学成果二等奖 生物学实验技术队伍建设与本科生创新能力培养模式及实践 （排名第二） 2010
甘肃省教学成果二等奖 生物学野外实习改革与实践 （排名第二）2008
甘肃省自然科学二等奖 我国石鸡属鸟类分类、生态和生态遗传研究（排名第三） 2007
社会工作
中国生理学会比较生理学专业委员会副主任委员 2015－
中国生物化学与分子生物学会第十届理事会理事 2010.8－2014.8
教育部高等学校生物科学与工程教学指导委员会委员2006-2010
中国动物学会两栖爬行动物学分会理事
甘肃省生理学会副理事长
其它信息
教学工作
主讲课程：动物生理学、生命科学导论、人体解剖生理学
教育部双语教学示范课程“动物生理学”（负责人）
甘肃省精品课程“动物生理学”（负责人）
甘肃省精品课程“生命科学导论”（负责人）
主持三项国家自然科学基金委“基础科学人才培养基金”项目
编写教材与著作
梅岩艾等主编 生理学原理 高等教育出版社 2011 （编者之一）
李仁德 董守良 陈强 人体及动物生理学实验指导 兰州大学出版社 2003
陈强 郭吉军 沙漠与动物 甘肃少儿出版社 1999
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