首都医科大学研究生导师介绍：李俊发

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姓名：李俊发性别：男职称：教授招生院所：基础医学院招生类型：科学学位(博)科学学位(硕)招生专业：神经生物学(博)神经生物学(硕)研究方向名称：脑缺血/低氧损伤和适应机制研究电子信箱：junfali@ccmu.edu.cn

社会任职

1.中国生理学会理事

2.北京生理科学会秘书长

3.《生理通讯》副主编

4.《基础医学与临床》常务编委

5.WorldJournalofAnesthesiology,EditorialBoardMember(编委)

6.ISRNPain,EditorialBoardMember(编委)

7.《中华眼底病杂志》编委

个人简历

1.198109-198608:首都医科大学医学学士

2.198608-198908:北京医学高等专科学校(现首都医科大学燕京医学院)助教，兼校团委书记

3.198908-199206:中国协和医科大学医学硕士

4.199206-199602:北京医学高等专科学校(现首都医科大学燕京医学院)讲师，兼教务处副处长

5.199602-200102:美国国立卫生研究院(NIH)访问学者

6.200102-200612:首都医科大学神经生物学系副研究员/副教授、副主任

7.200308-200607:首都医科大学神经生物学博士

8.200501-200912:首都医科大学分子生物学实验测试室主任

9.200701-200712:首都医科大学神经生物学系教授、博导、副主任

10.200801-:首都医科大学神经生物学系教授、博导、常务副主任

重要学术论文

1.WangQ,ZhaoQ,LiS,HanS,PengZ,LiJ(李俊发)*.PhosphorylatedCaMKIIlevelsincreaseinrats'centralnervoussystemafterlarge-doseintravenousremifentanil.MedicalScienceMonitorBasicResearch.2013,19:118-125.SCI

2.ZhaoL,LiuX,LiangJ,HanS,WangY,YinY,LuoY,LiJ(李俊发)*.Phosphorylationofp38MAPKmediateshypoxicpreconditioning-inducedneuroprotectionagainstcerebralischemicinjuryviamitochondriatranslocationofBcl-xLinmice.BrainResearch.2013,1503:78-88.SCI

3.ZhangE,ZhuX,HanS,ShanH,QiuZ,WangW,LiJ(李俊发)*,YangY.IncreasedexpressionsofTNFligandrelatedmolecule1Aanddeathreceptor3inbladdertissuesofpatientswithpainfulbladdersyndrome/interstitialcystitis.ExperimentalandTherapeuticMedicine.2013,5:282-286.SCI

4.ZhangN,LiY,LiJ(李俊发)*.Molecularpathfinding:insightintocerebralischemic/hypoxicinjuryandpreconditioningbystudyingPKC-isoformspecificsignalingpathways.ScienceSupplemental.2012,Suppl.:57-58.SCI

5.ShuL,LiT,HanS,JiF,PanC,ZhangB,LiJ(李俊发)*.Inhibitionofneuron-specificCREBdephosphorylationisinvolvedinPropofolandKetamine-inducedneuroprotectionagainstcerebralischemicinjuriesofmice.NeurochemicalResearch.2012,37:49-58.SCI

6.ShiY,WangC,HanS,PangB,ZhangN,WangJ,LiJ(李俊发)*.DeterminationofPKCisoform-specificproteinexpressioninpulmonaryarteriesofratswithchronichypoxia-inducedpulmonaryhypertension.MedicalScienceMonitor.2012,18(2):BR69-75.SCI

7.LiuC,PengZ,ZhangN,YuL,HanS,LiD,LiJ(李俊发)*.IdentificationofdifferentiallyexpressedmicroRNAsandtheirPKC-isoformspecificgenenetworkpredictionduringhypoxicpreconditioningandfocalcerebralischemiaofmice.JournalofNeurochemistry.2012,120:830-841.SCI

8.LiZ,LiJ(李俊发),BuX,LiuX,TankersleyCG,WangC,HuangK.Age-inducedaugmentationofp38MAPKphosphorylationinmouselung.ExperimentalGerontology.2011,46:694-702.SCI

9.BuX,ZhangN,YangX,LiuY,DuJ,LiangJ,XuQ,LiJ(李俊发)*.ProteomicanalysisofcPKCbetaII-interactingproteinsinvolvedinHPC-inducedneuroprotectionagainstcerebralischemiaofmice.JournalofNeurochemistry.2011,117(2):346-356.SCI

10.ZhangN,YinY,HanS,JiangJ,YangW,BuX,LiJ(李俊发)*.HypoxicpreconditioninginducedneuroprotectionagainstcerebralischemicinjuriesanditscPKCgamma-mediatedmolecularmechanism.NeurochemistryInternational.2011,58(6):684-692.SCI

11.WangY,MuX,WuJ,WuA,FangL,LiJ(李俊发)*,YueY.DifferentialRolesofPhosphorylatedAMPAReceptorGluR1SubunitsatSerine-831andSerine-845SitesinSpinalCordDorsalHorninaRatModelofPost-OperativePain.NeurochemicalResearch.2011,36(1):170-176.SCI

12.ZhangY,SuP,LiangP,LiuT,LiuX,LiuXY,ZhangB,HanT,ZhuYB,YinDM,LiJ(李俊发),ZhouZ,WangKW,WangY.TheDREAMproteinnegativelyregulatestheNMDAreceptorthroughinteractionwiththeNR1subunit.JournalofNeuroscience.2010,30(22):7575-7586.SCI

13.CuiW,LiY,LiS,WangR,LiJ(李俊发)*.Systemicadministrationoflidocainereducesmorphinerequirementsandpostoperativepainofpatientsundergoingthoracicsurgeryafterpropofol-remifentanil-basedanaesthesia.EuropeanJournalofAnesthesiology.2010,27(1):41-46.SCI

14.QuY,ShiX,ZhangH,SunW,HanS,YuC,LiJ(李俊发)*.VCAM-1siRNAreducesneointimalformationaftersurgicalmechanicalinjuryoftheratcarotidartery.JournalofVascularSurgery.2009,50(6):1452-1458.SCI

15.DingJ,DingN,WangN,LuQ,LuN,YangD,BuX,HanS,LiJ(李俊发)*.DeterminationofconventionalproteinkinaseCisoformsinvolvedinhighintraocularpressure-inducedretinalischemicpreconditioningofrats.VisionResearch.2009,49(3):315-321.SCI

16.WangY,WenY,FangY,PangH,GuoZ,ShiL,LiJ(李俊发).Experimentalvasoprotectionbyanovelerythrocyte-deriveddepressingfactorinratswitharterialcalcinosis.VasculPharmacol.2009,50(1-2):65-70.SCI

17.CuiX,LiJ(李俊发)*,LiT,JiF,BuX,ZhangN,ZhangB.Propofolandketamineinducedanestheticdepth-dependentdecreaseofCaMKIIphosphorylationlevelsinrathippocampusandcortex.JournalofNeurosurgicalAnesthesiology.2009,21(2):145-154.SCI

18.CuiW,LiY,LiS,YangW,JiangJ,HanS,LiJ(李俊发)*.Systemiclidocaineinhibitsremifentanil-inducedhyperalgesiaviatheinhibitionofcPKCgammamembranetranslocationinspinaldorsalhornofrats.JournalofNeurosurgicalAnesthesiology.2009,21(4):318-325.SCI

19.JiangJ,YangW,HuangP,BuX,ZhangN,LiJ(李俊发)*.IncreasedphosphorylationofEts-liketranscriptionfactor-1inneuronsofhypoxicpreconditionedmice.NeurochemicalResearch.2009,34:1443-1450.SCI

20.WuJ,ZhangX,NautaHJ,LinQ,LiJ(李俊发)*,FangL.JNK1regulateshistoneacetylationintrigeminalneuronsfollowingchemicalstimulation.Biochem.Biophys.ResCommun..2008,376:781-786.SCI

21.LiuY,LiJ(李俊发)*,YangJ,JiF,BuX,ZhangN,ZhangB.InhibitionofPKCgammamembranetranslocationmediatedmorphinepreconditioning-inducedneuroprotectionagainstoxygen-glucosedeprivationinthehippocampusslicesofmice.NeuroscienceLetters.2008,444(1):87-91.SCI

22.QiX,LinW,LiJ(李俊发),LiH,WangW,WangD,SunM.FluoxetineincreasestheactivityoftheERK-CREBsignalsystemandalleviatesthedepressive-likebehaviorinratsexposedtochronicforcedswimstress.NeurobiologyofDisease.2008,31(2):278-285.SCI

23.ZhangN,GaoG,BuX,HanX,FangL,LiJ(李俊发)*.Neuron-specificphosphorylationofc-JunN-terminalkinaseincreasedinthebrainofhypoxicpreconditionedmice.NeuroscienceLetters.2007,423(3):219-224.SCI

24.WeiY,WangN*,LuQ,ZhangN,ZhengD,LiJ(李俊发)*.Enhancedproteinexpressionsofsortilinandp75NTRinretinaofratfollowingelevatedintraocularpressure-inducedretinalischemia.NeuroscienceLetters.2007,429(2-3):169-174.SCI

25.HuangP,QiZ,BuX,ZhangN,HanS,FangL,LiJ(李俊发)*.Neuron-specificphosphorylationofmitogen-andstress-activatedproteinkinase-1involvedincerebralhypoxicpreconditioningofmice.JournalofNeuroscienceResearch.2007,85(6):1279-1287.SCI

26.WuJ,SuG,MaL,ZhangX,LeiY,LinQ,NautaHJ,LiJ(李俊发)*,FangL.Theroleofc-AMP-dependentproteinkinaseinspinalcordandpostsynapticdorsalcolumnneuronsinaratmodelofvisceralpain.NeurochemistryInternational.2007,50(5):710–718.SCI

27.JiaJ,WangX,LiH,HanS,ZuP,LiJ(李俊发)*.ActivationsofnPKCeandERK1/2wereinvolvedinoxygen-glucosedeprivationinducedneuroprotectionviaNMDAreceptorsinhippocampalslicesofmice.JournalofNeurosurgicalAnesthesiology.2007,19(1):18-24.SCI

28.KadekaroM,SuG,ChuR,LeiY,LiJ(李俊发)*,FangL.Effectsofnitricoxideonexpressionsofnitrosocysteineandcalcium-activatedpotassiumchannelsinthesupraopticnucleiandneurallobeofdehydratedrats.NeuroscienceLetters.2007,411(2):117-122.SCI

29.QiZ,BuX,HuangP,ZhangN,HanS,FangL,LiJ(李俊发)*.Increasedmembrane/nucleartranslocationandphosphorylationofp90KDribosomalS6kinaseinthebrainofhypoxicpreconditionedmice.NeurochemicalResearch.2007,32(9):1450-1459.SCI

30.BuX,HuangP,QiZ,ZhangN,HanS,FangL,LiJ(李俊发)*.Celltype-specificactivationofp38mitogen-activatedproteinkinasesinthebrainregionsofhypoxicpreconditionedmice.NeurochemistryInternational.2007,51(8):459-466.SCI

31.WuJ,LiJ(李俊发),LinQ,FangL.Signaltransductioninchronicpain.InternationalAnesthesiologyClinics.2007,45(2):73-81.

32.GuoSW,LiuMG,LongYL,RenLY,LuZM,YuHY,HouJF,LiH,GaoCY,CuiXY,AnYY,LiJF(李俊发),ZhaoLF,ChenJ.Region-orstate-relateddifferencesinexpressionandactivationofextracellularsignal-regulatedkinases(ERKs)innaiveandpain-experiencingrats.BMCNeuroscience.2007,8(1):53.SCI

33.LiJ(李俊发)*,YangC,HanS,ZuP,WuJ,XuQ,FangL.Increasedphosphorylationofneurogranininthebrainofhypoxicpreconditionedmice.NeuroscienceLetters.2006,391(3):150-153.SCI

34.Kadekaro-M，SuG，ChuR，LeiY，LiJ(李俊发)*，FangL.Nitircoxideup-regulatestheexpressionofcalcium-dependentpotassiumchannelsinthesupropticnucleiandneueallobeofratsfollowingdehdration.NeuroscienceLetters.2006,404(1-2):50-55.SCI

35.LiJ(李俊发)*,QuY,ZuP,HanS,GaoG,XuQ,FangL.Increasedisoform-specificmembranetranslocationofconventionalandnovelproteinkinaseCinhumanneuroblastomaSH-SY5Ycellsfollowingprolongedhypoxia.BrainResearch.2006,1093(1):25-32.SCI

36.MengF,LiJ(李俊发),ZhangB,JiF.nPKCeandNMDAreceptorsparticipateinneuroprotectioninducedbymorphinepretreatment.JournalofNeurosurgicalAnesthesiology.2006,18(2):119-124.SCI

37.LongC,GaoY,GaoG,HanS,ZuP,FangL,LiJ(李俊发)*.DecreasedphosphorylationandproteinexpressionofERK1/2inthebrainofhypoxicpreconditionedmice.NeuroscienceLetters.2006,397(3):307-312.SCI

38.GaoY,GaoG,LongC,HanS,ZuP,FangL,LiJ(李俊发)*.EnhancedphosphorylationofcyclicAMPresponseelementbindingproteininthebrainofmicefollowingrepetitivehypoxicexposure.BiochemicalandBiophysicalResearchCommunications.2006,340(2):661-667.SCI

39.QiX,LinW,LiJ(李俊发),PanY,WangW.Thedepressive-likebehaviorsarecorrelatedwithdecreasedphosphorylationofmitogen-activatedproteinkinasesinratbrainfollowingchronicforcedswimstress.BehaviouralBrainResearch.2006,175(2):233-240.SCI

40.ZhaoL,WangN,JiangL,LongC,LiJ(李俊发)*.Unilateralopticnervetransectionup-regulateHsp70proteinexpressioninlateralgeniculatenucleusofrats.NeuroscienceLetters.2006,404(1-2):44-49.SCI

41.WuJ,SuG,MaL,ZhangX,LeiY,LiJ(李俊发),LinQ,FangL.ProteinkinasesmediateincrementofthephosphorylationofcyclicAMP-responsiveelementbindingproteininspinalcordofratsfollowingcapsaicininjection.MolecularPain.2005,1:26-34.SCI

42.LiJ(李俊发)*,NiuC,HanS,ZuP,LiH,XuQ,FangL.IdentificationofproteinkinaseCisoformsinvolvedincerebralhypoxicpreconditioningofmice.BrainResearch.2005,1060(1-2):62-72.SCI

43.NiuC,LiJ(李俊发)*,CuiX,HanS,ZuP,LiH,XuQ.ChangesincPKCisoform-specificmembranetranslocationandproteinexpressioninthebrainofhypoxicpreconditionedmice.NeuroscienceLetters.2005,384(1-2):1-6.SCI

44.HuangKP,HuangFL,JagerT,LiJ(李俊发),ReymannKG,BalschunD.Neurogranin/RC3enhanceslong-termpotentiationandlearningbypromotingcalcium-mediatedsignaling.JournalofNeuroscience.2004,24(47):10660-10669.SCI

45.WuJ,LiJ(李俊发),HuangKP,HuangFL.AttenuationofproteinkinaseCandcamp-dependentproteinkinasesignaltransductionintheneurograninknockoutmouse.JournalofBiologicalChemistry.2002,277(22):19498-19505.SCI

46.LiJ(李俊发),HuangFLandHuangKP.GlutathiolationofproteinsbyglutathionedisulfideS-oxidederivedfromS-nitrosoglutathione.Modificationsofratbrainneurogranin/RC3andneuromodulin/GAP-43.JournalofBiologicalChemistry.2001,276(5):3098-3150.SCI

47.HuangKP,HuangFL,LiJ(李俊发),SchuckP,McPhieP.Calcium-sensitiveinteractionbetweencalmodulinandmodifiedformsofratbrainneurogranin/RC3.Biochemistry.2000,39(24):7291-7299.SCI

48.PakJH,HuangFL,LiJ(李俊发),BalschunD,ReymannKG,ChiangC,WestphalH,andHuangKP.Involvementofneurogranininthemodulationofcalcium/calmodulin-dependentproteinkinaseII,synapticplasticity,andspatiallearning:Astudywithknockoutmice.ProcNatlAcadSciUSA(PNAS).2000,97(21):11232-11237.SCI

49.LiuJ,HeL,CollinsI,GeH,LibuttiD,LiJ(李俊发),EglyJ,andLevensD.TheFBPinteractingrepressortargetsTFIIHtoinhibitactivatedtranscription.MolecularCell.2000,5:331-341.SCI

50.LiJ(李俊发),PakJH,HuangFLandHuangKP.N-methyl-D-aspartateinducesneurogranin/RC3oxidationinratbrainslices.JournalofBiologicalChemistry.1999,274(3):1294-1300.SCI

主编或副主编的著作/译著

1.《细胞信号转导研究技术》,主编,中国协和医科大学出版社,200808