南华大学公共卫生学院导师：杨细飞

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南华大学公共卫生学院导师：杨细飞正文

[导师姓名]
杨细飞

[所属院校]
南华大学

[基本信息]
导师姓名：杨细飞
性别：男
人气指数：6036
所属院校：南华大学
所属院系：公共卫生学院
职称：研究员
导师类型：
招生专业：公共卫生硕士

[通讯方式]
办公电话：0755-25601914
电子邮件：xifeiyang@gmail.com
通讯地址：广东省深圳市南山区龙苑路8号

[个人简述]
获广东省科学技术奖二等奖、中华医学奖三等奖、深圳市自然科学奖一等奖及深圳市科技进步奖二等奖各1项。国际学术期刊J Alzheimers Dis杂志副编辑（Associate Editor）及Front Neurosci杂志编委；10多个国际主流SCI期刊审稿专家。

[科研工作]
2005/8-2007/7 香港大学，医学院，访问学者2007/8-2009/7 香港大学，医学院，访问学者/博士后2009/8-至今 深圳市疾病预防控制中心/深圳市预防医学研究所，广东省医学重点实验室 副研究员、深圳大学特约教授、四川大学华西医学中心（原华西医科大学）客座副教授 硕士研究生导师1. Ming Ying, Xiaojing Sui,Yanling Zhang, Qian Sun, Zhongsen Qu, Xiaobin Luo, Raymond Chuen-Chung Chang, Jiazuan Ni, Jianjun Liu and Xifei Yang*(通讯作者). Identification of Novel Key Molecules Involved in Spatial Memory Impairment in Triple Transgenic Mice of Alzheimer’s Disease. Mol Neurobiol. 2016, In press. (2015最新影响因子: 5.137)2. Qian Sun, Ming Ying, Quan Ma, Zhijun Huang, Liangyu Zou, Jianjun Liu, Zhixiong Zhuang, Xifei Yang*(通讯作者). Proteomic Analysis of Hippocampus in Mice Following Long-term Low Levels of Copper. Toxicol Res. 2016, Accepted. (2015最新影响因子: 3.983)3. Xing R, Zhang Y, Xu H*, Luo X, Chang RC, Liu J, Yang X* (通讯作者). Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment. Oncotarget. 2016 Mar 28. doi: 10.18632/oncotarget.8428. [Epub ahead of print]. [PMID: 27034165]. (2015最新影响因子: 6.359)4. Wu Y, Luo X, Liu X, Liu D, Wang X, Guo Z, Zhu L, Tian Q, Yang X* (通讯作者), Wang JZ*. Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models. Sci Rep. 2015 Oct 14 5:15032. [PMID: 26463268]. (2015最新影响因子: 5.578)5. Yang X* (通讯作者), Zhang Y, Xu H, Luo X, Yu J, Liu J, Chang RC. Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. Curr Top Med Chem. 2016 16(8):858-866. (特邀综述) . (2015最新影响因子: 3.402)6. Zhang Y, Xing R, Luo X, Xu H, Chang RC, Zou L, Liu J, Yang X* (通讯作者). Anxiety-like Behavior and Dys-regulation of miR-34a in Triple Transgenic Mice of Alzheimer’s Disease. Eur Rev Med Pharmacol Sci. 2016. In press. (2015最新影响因子: 1.213)7. Yang X, He C, Li J, Chen H, Ma Q, Sui X, Tian S, Ying M, Zhang Q, Luo Y, Zhuang Z, Liu J*. Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells. Toxicol Lett. 2014 229(1):240-249. [PMID: 24831964]. (2015最新影响因子: 3.262)8. Yang X, Liu J*, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, Zhang B, Zhuang Z. SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol. 2010 19 7(1):1. [PMID: 20180970]. (2015最新影响因子: 7.113 引用次数: 62)9. Yang Y#, Yang XF# (共同第一作者), Wang YP, Tian Q, Wang XC, Li HL, Wang Q and Wang JZ*. Inhibition of protein phosphatases induces transport deficits and axonopathy. J Neurochem. 2007 102(3): 878-886. [PMID: 17472709]. (2015最新影响因子: 4.281) 10. Zhang C*, #, Yang X# (共同第一作者), Li L, Sui X, Tian Q, Wei W, Wang J, Liu G*. Hypoxia induced tau phosphorylation and memory deficit in rats. Neurodegener Dis. 2014 14(3):107-116. [PMID: 24993525]. (2015最新影响因子: 3.511) 11. Yang XF, Yang Y, Fu ZQ, Li Y, Feng J, Luo JZ, Zhang QY, Wang Q and Tian Q*. Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol. 2011 25(8):1118-25. [PMID: 20542922]. (2015最新影响因子: 3.593)12. Ren X#, Yang X# (共同第一作者), Hong WX#, Huang P, Wang Y, Liu W, Ye J, Huang H, Huang X, Shen L, Yang L, Zhuang Z, Liu J* . Identification of the proteins related to SET-mediated hepatic cytotoxicity of trichloroethylene by proteomic analysis. Toxicol Lett. 2014. 227(1):12-19. [PMID: 24631019]. (2015最新影响因子: 3.262)13. Yang X, Jiang Y, Li J, Hong WX, Wu D, Huang X, Huang H, Zhou L, Yang L, Yuan J, Zhuang Z, Liu J*. Lentivirus-mediated silencing of I2PP2A through RNA interference attenuates trichloroethylene-induced cytotoxicity in human hepatic L-02 cells. Toxicol Lett. 2012. 209(3):232-238. [PMID: 22245669]. (2015最新影响因子: 3.262) 14. Yang X, Shen Z, Zhang B, Yang J, Hong WX, Zhuang Z, Liu J*. Silica nanoparticles capture atmospheric lead: Implications in the treatment of environmental heavy metal pollution. Chemosphere. 2013 90(2):653-656. [PMID: 23084516]. (2015最新影响因子: 3.340)15. Yang X, Dai G, Li G*, Yang ES. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease. J Mol Neurosci. 2010 41(1):110-113. [PMID: 19834824]. (2015最新影响因子: 2.343 引用次数: 45)16. Yang X, Yang Y, Li G*, Wang J, Yang ES. Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol Neurosci. 2008 34(2):165-171. [PMID: 18181031]. (2015最新影响因子: 2.343 引用次数: 44)17. Luo Y#, Yang X# (共同第一作者), Zhao S, Wei C, Yin Y, Liu T, Jiang S, Xie J, Wan X, Mao M, Wu J*. Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons. Neurochem Int. 2013 63(8):826-831. [PMID: 23770272]. (2015最新影响因子: 3.092)18. Luo Y, Liu X, Zheng Q, Wan X, Ouyang S, Yin Y, Sui X, Liu J, Yang X*(通讯作者). Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H(2)O(2)-activated calcium signaling pathway in mouse hippocampal neurons. Biochem Biophys Res Commun. 2012 425(2):473-477. [PMID: 22846576]. (最新影响因子: 2.297)19. Yang X, Yang Y, Luo Y, Li G*, Wang J, Yang ES. Hyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with Alzheimer presenilin 1 mutation. Cell Mol Neurobiol. 2009 29(4):497-501. [PMID: 19137424]. (2015最新影响因子: 2.506)20. Yang X*(通讯作者), Yang Y, Liu J, Li G, Yang E. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochem Res. 2012 37(1):15-22. [PMID: 21842270]. (2015最新影响因子: 2.593)21. Sui X, Ren X, Huang P, Li S, Ma Q, Ying M, Ni J, Liu J*, Yang X*(通讯作者). Proteomic analysis of serum proteins in triple transgenic Alzheimer's disease mice: implications for identifying biomarkers for use to screen potential candidate therapeutic drugs for early Alzheimer's disease. J Alzheimers Dis. 2014 40(3):575-586. [PMID: 24496070]. (2015最新影响因子: 4.151)（被World Medical Frontier（ISSN: 2328-0166）《世界医学前沿》收录为Featured article，详见http://biomedfrontiers.org/alzheimer-2014-12-17）22. Ma Q, Ying M, Sui X, Huang H, Yang L, Huang X, Zhuang Z, Liu J ,Yang X* (通讯作者). Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015 43(4): 1413-1427. [PMID: 25159668]. (2015最新影响因子: 4.151).23. Yu J, Luo X, Xu H*, Ma Q, Yuan J, Li X, Chang RC, Qu Z, Huang X, Zhuang Z, Liu J, Yang X*(通讯作者). Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. J Alzheimers Dis. 2015 44(2):455-469. [PMID: 25352456]. (2015最新影响因子: 4.151).24. Sui X, Liu J, Yang X*(通讯作者). Cerebrospinal fluid biomarkers of Alzheimer’s disease. Neurosci Bull. 2014 30(2): 233-242. [PMID: 24733653]. (2015最新影响因子: 2.509). (Invited review/特邀综述)25. Du LL, Wang L, Yang XF, Wang P, Li XH, Chai DM, Liu BJ, Cao Y, Xu WQ, Liu R, Tian Q, Wang JZ, Zhou XW. Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis. Mol Neurobiol. 2016 Feb 24. [Epub ahead of print]. [PMID: 26910815]. (2015最新影响因子: 5.137)26. Peng Y, Xiong X, Tong X, Li M, Yang X, Hu G, Geng Y, Li J. Correlation of the content of hepatitis B core antigen in peripheral blood mononuclear cells with HBV virus load. Diagn Microbiol Infect Dis. 2015 Sep 30. pii: S0732-8893(15)00351-X. doi: 10.1016/j.diagmicrobio.2015.09.017. [Epub ahead of print]. [PMID: 26680298]. (2015最新影响因子: 2.457)27. Ho YS, Yang X, Yeung SC, Chiu K, Lau CF, Tsang AW, Mak JC, Chang RC*. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. PLoS One. 2012 7(5):e36752. [PMID: 22606286]. (2015最新影响因子: 3.234)28. Ho YS, Yang X, Lau JC, Hung CH, Wuwongse S, Zhang Q, Wang J, Baum L, So KF, Chang RC*. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. J Alzheimers Dis. 2012 28(4):839-854. [PMID: 22101233]. (2015最新影响因子: 4.151)29. Ho YS, Yu MS, Yang XF, So KF, Yuen WH, Chang RC*. Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 2010 19(3):813-827. [PMID: 20157238]. (2015最新影响因子: 4.151 引用次数: 42)30. Li G*, Jack CR, Yang XF, Yang ES. Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: an in vivo volume MRI study. Biofactors. 2008 32(1-4):169-178. [PMID: 19096113]. (2015最新影响因子: 4.592 引用次数: 18) 31. Hong WX, Yang L, Chen M, Yang X, Ren X, Fang S, Ye J, Huang H, Peng C, Zhou L, Huang X, Yang F, Wu D, Zhuang Z, Liu J*. Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-Binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells. Toxicol Appl Pharmacol. 2012 263(2): 259-272. [PMID: 22771849]. (2015最新影响因子: 3.705)32. Hong WX, Liu W, Zhang Y, Huang P, Yang X, Ren X, Ye J, Huang H, Tang H, Zhou G, Huang X, Zhuang Z, Liu J*. Identification of serum biomarkers for occupational medicamentosa-like dermatitis induced by trichloroethylene using mass spectrometry. Toxicol Appl Pharmacol. 2013 273(1):121-129. [PMID: 23994554]. (2015最新影响因子: 3.705)33. Liu J, Liu J, Yuan J, Tao G, Wu D, Yang X, Yang L, Huang H, Zhou L, Xu X, Hu J, Zhuang Z*. Proteome of melamine urinary bladder stones and implication for stone formation. Toxicol Lett. 2012 212（3）:307-314. [PMID: 22688180]. (2015最新影响因子: 3.262) 34. Huang P, Ren X, Huang Z, Yang X, Hong W, Zhang Y, Zhang H, Liu W, Huang H, Huang X, Wu D, Yang L, Tang H, Zhou L, Li X, Liu J*. Serum proteomic analysis reveals potential serum biomarkers for occupational medicamentosa-like dermatitis caused by trichloroethylene. Toxicol Lett. 2014 229(1):101-110. (2015最新影响因子: 3.262) 35. Ke Y*, Lv Z, Yang X, Zhang J, Huang J, Wu S, Li YR. Compensatory effects of hOGG1 for hMTH1 in oxidative DNA damage caused by hydrogen peroxide. Toxicol Lett. 2014, 230(1): 62-68. [PMID: 25127756]. (2015最新影响因子: 3.262)36. Li J, Yang XF, Ren XH, Meng XJ, Huang HY, Zhao QH, Yuan JH, Hong WX, Xia B, Huang XF, Zhou L, Liu JJ, Zou F*. Stable SET knockdown in breast cell carcinoma inhibits cell migration and invasion. Biochem Biophys Res Commun. 2014, 453(9):7-12. [PMID: 25234598]. (2015最新影响因子: 2.297)37. Liu J, Huang P, He Y, Hong WX, Ren X, Yang X, He Y, Wang W, Zhang R, Yang H, Zhao Z, Huang H, Chen L, Zhao D, Xian H, Yang F, Ma D, Yang L, Yin Y, Zhou L, Chen X, Cheng J. Serum amyloid A and clusterin as potential predictive biomarkers for severe hand, foot and mouth disease by 2D-DIGE proteomics analysis. PLoS One. 2014 9(9):e108816. [PMID: 25268271]. (2015最新影响因子: 3.234 引用次数: 12)38. Ho WL, Leung Y, Cheng SS, Lok CK, Ho YS, Baum L, Yang X, Chiu K, Chang RC. Investigating degeneration of the retina in young and aged tau P301L mice. Life Sci. 2015 124:16-23. [PMID: 25592136]. (最新影响因子: 2.702)39. Li G, Liang JM, Li PW, Yao X, Pei PZ, Li W, He QH, Yang X, Chan QC, Cheung PY, Ma QY, Lam SK, Cheng PY, Yang ES*. Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave. Pflugers Arch. 2011 462(4):587-597. [PMID: 21796340]. (2015最新影响因子: 4.101 引用次数: 8) (美国有线新闻网(CNN)等媒体报道了这一由香港大学、北京大学、深圳市疾病预防控制中心等机构组成的研究团队历经八年的研究成果) 40. Zhang H, Hong WX, Ye J, Yang X, Ren X, Huang A, Yang L, Zhou L, Huang H, Wu D, Huang X, Zhuang Z, Liu J*. Analysis of trichloroethylene-induced global DNA hypomethylation in hepatic L-02 cells by liquid chromatography-electrospray ionization tandem mass spectrometry. Biochem Biophys Res Commun. 2014 446(2):590-595. [PMID: 24632203]. (2015最新影响因子: 2.297)41. Lao W, Fang M*, Yang X. FK506-binding protein 51 (FKBP5) gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic thrombocytopenic purpura. Mol Med Report. 2012 6(4): 787-790. [PMID: 22825419]. (2015最新影响因子：1.554) 42. Luo Y, Zhou X*, Yang X, Wang J. Homocysteine induces tau hyperphosphorylation in Rats. Neuroreport. 2007 18(18): 2005-2008. [PMID: 18007203]. (2015最新影响因子: 1.520 引用次数: 24)43. Hong WX, Ye JB, Chen MT, Yan Y, Zhou GF, Yang XF, Yang L, Ren XH, Huang HY, Zhou L, Huang XF, Zhuang ZX, Liu JJ*. Trichloroethylene induces biphasic concentration-dependent changes in cell proliferation and the expression of SET-associated proteins in human hepatic L-02 cells. Biomed Environ Sci. 2013 26(7):618-621. [PMID: 23895710] (2015最新影响因子: 1.653 引用次数: 0)44. Lao W, Yang X, Fang M*, Yang X. Polymorphism and expression of macrophage migration inhibitory factor does not contribute to glucocorticoid resistance in idiopathic thrombocytopenic purpura. Pharmazie. 2013 68: 846–849. [PMID: 24273891] (2015最新影响因子: 1.052)45. Zhao XG, Zheng Y, Chan QC, Yang XF, Li G, Yang ES*. Biopsy needle as MRE driver for tumor detection. Conf Proc IEEE Eng Med Biol Soc. 2007 2007:2050-2052. [PMID: 18002389]. (EI indexed)46. Lau CF, Ho YS, Hung CH, Wuwongse S, Poon CH, Chiu K, Yang X, Chu LW, Chang RC*. Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons. Biomed Res Int. 2014 2014:103906. [PMID: 25045655]. (2015最新影响因子: 1.579)47. Liu W, Hong WX, Zhang Y, Huang P, Yang X, Ren X, Huang H, Liu J. Proteomic profiling of occupational medicamentosa-like dermatitis induced by trichloroethylene in serum based on MALDI-TOF MS. Clin Exp Med. 2014 Dec 5. [Epub ahead of print]. [PMID: 25475505]. (2015最新影响因子: 2.959)48. Liu W, Zhou L, Wang H, Zheng B, Wu D, Yang X, Liu J*. CYP2E1 gene rs6413420 polymorphism was first found in the Bouyei ethnic group of China. Int J Clin Exp Med. 2014 7(10):3612-3620. eCollection 2014. [PMID: 25419409]. (2015最新影响因子: 1.277)49. Hong WX, Huang A, Lin S, Yang X, Yang L, Zhou L, Huang H, Wu D, Huang X, Xu H, Liu J. Differential expression profile of membrane proteins in L-02 cells exposed to trichloroethylene. Toxicol Ind Health. 2015 Jun 4. pii: 0748233715588438. [Epub ahead of print] [PMID: 26045551]. (2015最新影响因子: 1.859 引用次数: 0)50. Ren X, Li J, Xia B, Liu W, Yang X, Hong WX, Huang P, Wang Y, Li S, Zou F, Liu J. Phosphoproteomic analyses of L-02 liver cells exposed to trichloroethylene. Toxicol Mech Methods. 2015 May 27:1-8. [Epub ahead of print] [PMID: 26018768]. (2015最新影响因子: 1.517)现任中国毒理学会神经毒理专业委员会委员，广东省毒理学会理事，国际阿尔茨海默病协会会员，深圳市预防医学会分子毒理学专业委员会委员。

[教育背景]
1997/9-2002/6 武汉科技大学，医学院，本科/医学学士
2002/9-2007/6 华中科技大学，同济医学院，博士（硕博连读），导师：王建枝教授（期间于2005年-2007年以访问学者身份赴香港大学医学院开展课题合作研究）
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