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山东大学生命科学学院导师：王金星正文
王金星 教授
博士生导师
济南市山东大学生命科学学院
jxwang@sdu.edu.cn
教育背景
男，1955年5月生，博士，教授。2000年被聘为博士生导师
中国动物学会理事，中国海洋与湖沼学会理事，山东动物学会常务副理事长，山东生化与分子生物学会副理事长。享受国务院政府特殊津贴。
1981年山东师范大学本科毕业、1984年山东大学硕士研究生毕业，留校工作。1998年获博士学位。曾分别赴日本山口大学（1992）、九州工业大学（2000）、德国吉森大学（2002）等进行合作研究。
培养的博士生有1人获山东省优秀博士论文，多人获山东大学校长奖学金。研究生毕业后适合从事动物学、水产科学、生化与分子生物学和生物工程等方面的教学与科研工作。
研究方向
研究领域为动物学、生化与分子生物学。研究方向为无脊椎动物先天免疫，包括先天免疫的模式识别、信号转导途径和效应分子(主要是抗菌肽)及其功能。讲授无脊椎动物天然免疫等课程。
近十几年来一直从事无脊椎动物先天免疫研究。主持和参加国家自然科学基金、国家863、973、国家攻关和省部级等项目20余项。在The Journal of Immunology, Cellular and Molecular Life Sciences，Molecular Immunology, Developmental and Comparative immunology等国内外刊物发表论文100余篇。获国家发明专利5项。近年来在无脊椎动物先天免疫研究方面取得了较好的进展，获教育部2010年高等学校科学研究优秀成果奖—自然科学一等奖。 主要在下列几个方面开展了较系统的工作。
1．感染的模式识别研究：多种免疫识别受体的发现，改变了先天免疫的早期的概念，先天免疫可以通过模式识别受体(PRRs)识别不同的病原相关分子模式(PAMPs)，而实现对不同病原的识别，因而存在着某种特异性。我们以对虾为材料，发现了多种模式识别受体分子，对它们的性质和功能进行了较系统的研究。包括革兰氏阴性菌结合蛋白（Molecular Immunology，2007）、6种C-型凝集素（Molecular Immunology，2008, 2009，Developmental & Comparative Immunology, 2009; Fish & Shellfish Immunology,2009）等，发现它们具有结合不同病原菌或不同病原相关分子模式的功能。并提出对虾围食膜蛋白(Molecular Immunology，2006)和血小板反应素(Molecular Immunology，2006)可能与免疫有关，具有免疫识别的作用。
2．免疫信号的调整与信号转导途径：在模式生物研究中，发现了多种信号转导途径与动物的先天免疫有关。包括在Toll样途径、免疫缺陷信号转导途径（Imd）途径、Jak-Stat途径、转化生长因子beta途径、p38丝裂原活化的蛋白激酶途径、细胞程序化死亡途径和胰岛素样受体途径等。我们近期的工作发现了多种可能参与免疫信号的调整的蛋白酶及其抑制因子，包括含有Clip结构域的丝氨酸蛋白酶及其同系物(Fish & Shellfish Immunology, 2009)、丝氨酸蛋白酶抑制因子(Fish & Shellfish Immunol, 2009)。同样发现了多种与免疫信号转导相关的关键分子，包括Toll样受体及其配体Sp?tzle (Fish & Shellfish Immunology,2009) 、IMD、STAT及多种磷酸激酶等相关的分子。初步实验结果显示Toll途径可能参与Crustin 抗菌肽表达的调控。
3．免疫效应分子的研究：无脊椎动物主要的免疫效应分子为抗菌肽（蛋白）。研究了中国对虾和家蝇的多种抗菌肽的性质、功能与表达调控，并成功进行了原核和真核重组表达。首先对家蝇的抗菌肽进行研究，克隆到了多种家蝇抗菌肽（包括天蚕素、防御素、攻击素和溶菌酶等）基因，对其时空表达与调控进行了研究，并进行了原核和/或真核重组表达，获得了有抗菌活性的重组抗菌肽（Developmental & Comparative Immunology 2006， Cellular and Molecular Life Sciences 2006）。对虾抗菌肽研究： 对中国明对虾抗菌肽——对虾素基因进行了克隆与表达调控研究，得到2类（共4种）对虾素基因，在对虾中首次发现和命名对虾素5，在大肠杆菌和酵母菌中成功表达了两类对虾素这些抗菌肽均显示出广谱抗菌活性，具有潜在的应用前景(Fish & Shellfish Immunology 2004；Protein expression and purification 2004；Molecular Immunology，2007)。发现了多种含有WAP结构域的抗菌肽，包括SWD（Aquaculture，2008）、甲壳肽（Fish & Shellfish Immunology，2010）、抗脂多糖因子、溶菌酶等，并进行了重组表达的性质研究，得到了有抗菌活性的上述分子。
4．抗病毒机理的研究：RNA干扰途径在无脊椎动物中具有重要的抗病毒功能。我们在中国明对虾中发现了转录激活反应RNA结合蛋白(TRBP)与真核翻译起始因子6(eIF6)之间存在着相互作用，可能与是RNAi途径的重要组成成分(Journal of Immunology, 2009)。另外还发现了多种可能参与抗病毒反应的蛋白(Molecular Biology Reports，2009)。
承担课题
在研项目包括973 、863、国家自然科学基金、海外青年合作研究基金（杰出青年基金B）和高校博士点基金等。
研究成果及发表论文
代表性论著 (* 通讯作者Corresponding author):
54. Chen AJ, Wang S, Zhao XF, Yu XQ, Wang JX*. E2 Enzyme from Chinese White Shrimp Inhibits Replication of White Spot Syndrome Virus and Ubiquitinates its RING Domain Proteins. J. Virol. 2011, doi:10.1128/JVI.00487-11.
53. Ren Q, Zhou J, Zhao XF, Wang JX*. Potential role of single hotdog fold thioesterase in the antiviral response of Fenneropenaeus chinensis. Fish Shellfish Immunol. 2011 Feb 26. doi:10.1016/j.fsi.2011.02.019
52. Zhang XW, Wang XW, Sun C, Zhao XF, Wang JX*. C-type lectin from red swamp crayfish Procambarus clarkii participates in cellular immune response. Arch Insect Biochem Physiol. 2011 Mar;76(3):168-84.
51. Sun C, Shao HL, Zhang XW, Zhao XF, Wang JX*. Molecular cloning and expression analysis of signal transducer and activator of transcription (STAT) from the Chinese white shrimp Fenneropenaeus chinensis. Mol Biol Rep. 2011 Jan 19. DOI 10.1007/s11033-011-0681-x
50. Ren Q, Zhou J, Zhao XF, Wang JX*. Molecular cloning and characterization of a receptor for activated protein kinase C1 (RACK1) from Chinese white shrimp; Fenneropenaeus chinensis. Dev Comp Immunol. 2011 Jan 14. doi:10.1016/j.dci.2011.01.004
49. Ren Q, Zhao XF, Wang JX*. Identification of three different types of serine proteases (one SP and two SPHs) in Chinese white shrimp. Fish Shellfish Immunol. 2011 Feb; 30(2):456-66. doi:10.1016/j.fsi.2010.11.009
48. Ren Q, Zhou J, Sun SS, Kang CJ, Zhao XF, Wang JX*. Molecular cloning and expression pattern analysis of two novel disulfide isomerases in shrimp. Comp Biochem Physiol C Toxicol Pharmacol. 2011 Apr;153(3):301-9. doi:10.1016/j.cbpc.2010.11.007
47. Sun C, Xu WT, Zhang HW, Dong LP, Zhang T, Zhao XF, Wang JX* An anti-Lipopolysaccharide factor from red swamp crayfish, Procambarus Clarkii, exhibited antimicrobial activities in vitro and in vivo. Fish Shellfish Immunol. 2011 Jan;30(1):295-303. doi:10.1016/j.fsi.2010.10.022
46. Wang XW, Zhang HW, Li X, Zhao XF, Wang JX*. Characterization of a C-type lectin (Pclec2) as an upstream detector in the prophenoloxidase activating system of red swamp crayfish. Fish Shellfish Immunol. 2011 Jan; 30(1):241-7. doi:10.1016/j.fsi.2010.10.012
45. Zhang HW, Sun C, Sun SS, Zhao XF, Wang JX* Functional analysis of two invertebrate-type lysozymes from red swamp crayfish, Procambarus clarkii. Fish Shellfish Immunol. 2010 Dec; 29(6):1066-72. Doi: 10.1016/j.fsi.2010.08.023
44. Chai YM Yu SS, Zhao XF, Zhu Q, Wang JX*, Comparative proteomic profiles of the hepatopancreasin Fenneropenaeus chinensis response to white spot syndrome virus. Fish Shellfish Immunol. 2010 Sep;29(3): 480-6. doi:10.1016/j.fsi.2010.05.009
43. Ren Q, Zhang XW, Sun YD, Sun SS, Zhou J, Zhao XF, Wang JX*. Two Cysteine proteinases respond to bacterial and WSSV challenge in Chinese white shrimp Fenneropenaeus chinensis. Fish Shellfish Immunol. 2010 Oct;29(4):551-6. DOI: 10.1016/ j.fsi.2010.03.002
42. Wang Q, Liu Y, He H-J, Zhao X-F*, Wang J-X*. Immune responses of Helicoverpa armigera to different kinds of pathogens. BMC Immunology, 2010, BMC Immunol. 2010 Mar 3;11:9.
41. Xu W-T, Wang X-W, Zhang X-W, Zhao X-F, Yu X-Q, Wang J-X*. A new C-type lectin (FcLec5) from the Chinese white shrimp Fenneropenaeus chinensis. Amino Acids, 2010 Nov;39(5):1227-39. DOI 10.1007/s00726-010-0558-72010.
40. Li X-C, Zhang R-R, Sun R-R, Lan J-F, Zhao X-F, Wang J-X*. Three Kazal-type serine proteinase inhibitors from the red swamp crayfish Procambarus clarkii and the characterization, function analysis of hcPcSPI2. Fish Shellfish Immunol. 2010 May-Jun; 28(5-6):942-951.
39. Shi X-Z, Li X-C, Wang S, Zhao X-F, Wang J-X*. Transcriptome analysis of hemocytes and hepatopancreas in red swamp crayfish, Procambarus clarkii, challenged with white spot syndrome virus. Invertebrate Survival Journal, 2010, Apr; 7: 119-131.
38. Sun C, Du XJ, Xu WT, Zhang HW, Zhao XF, Wang JX*. Molecular cloning and characterization of three crustins from the Chinese white shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol. 2010 Apr; 28(4):517-24.
37. Ren Q, Zhang RR, Zhao XF, Wang JX*. A thioredoxin response to the WSSV challenge on the Chinese white shrimp, Fenneropenaeus chinensis. Comp Biochem Physiol C Toxicol Pharmacol. 2010 Jan;151(1):92-98.
36. Du ZQ, Li XC, Wang ZH, Zhao XF, Wang JX*. A single WAP domain (SWD)-containing protein with antipathogenic relevance in red swamp crayfish, Procambarus clarkii. Fish Shellfish Immunol. 2010; 28(1): 134-142
35. Shi XZ, Zhang RR, Jia YP, Zhao XF, Yu XQ*, Wang JX*. Identification and molecular characterization of a Sp?tzle-like protein from Chinese shrimp (Fenneropenaeus chinensis). Fish Shellfish Immunol. 2009;27(5):610-7.
34. Ren Q, Du ZQ, Zhao XF, Wang JX*. An acyl-CoA-binding protein (FcACBP) and a fatty acid binding protein (FcFABP) respond to microbial infection in Chinese white shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol. 2009; 27: 739-747.
33. Wang XW, Xu WT, Zhang XW, Zhao XF, Yu XQ*, Wang JX*. A C-type lectin is involved in the innate immune response of Chinese white shrimp. Fish Shellfish Immunol. 2009 Sep, 27(4): 556-562.
32. Li XC, Wang XW, Wang ZH, Zhao XF, Wang JX*. A three-domain Kazal-type serine proteinase inhibitor exhibiting domain inhibitory and bacteriostatic activities from freshwater crayfish Procambarus clarkii. Dev Comp Immunol. 2009 Dec; 33(12): 1229-1238.
31. Du ZQ, Ren Q, Zhao XF, Wang JX*. A double WAP domain (DWD)-containing protein with proteinase inhibitory activity in Chinese white shrimp, Fenneropenaeus chinensis.Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):203-10.
30. Wang XW, Zhang X-W, Xu W-T, Zhao X-F, Wang J-X*. A novel C-type lectin (FcLec4) facilitates the clearance of Vibrio anguillarum in vivo in Chinese white shrimp. Dev Comp Immunol. 2009 Sep;33(9):1039-47.
29. Wang ZH, Zhao XF, Wang JX*. Characterization, kinetics, and possible function of Kazal-type proteinase inhibitors of Chinese white shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol. 2009 Jun; 26(6): 885-897.
28. Wang S , Liu N, Chen AJ, Zhao XF, Wang JX*. TRBP homologue interacts with Eukaryotic Initiation Factor 6 (eIF6) in Fenneropenaeus chinensis. J Immunol. 2009 May 1; 182(9):5250-5258.
27. Ren Q, Xu ZL, Wang XW Zhao XF, Wang JX*. Clip domain serine protease and its homolog respond to Vibrio challenge in Chinese white shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol., 2009 May; 26(5):787-798.
26. Zhang XW, Xu WT, Wang XW, Mu Y, Zhao XF, Yu XQ*, Wang JX*. A novel C-type lectin with two CRD domains from Chinese shrimp Fenneropenaeus chinensis functions as a pattern recognition protein. Mol. Immunol., 2009 May; 46(8-9): 1626-1637.
25. Shi XZ, Ren Q, Zhao XF, Wang JX*. Expression of four trypsins from the Chinese shrimp, Fenneropenaeus chinensis, as regulated by pathogenic infection. Comp Biochem Physiol. B 2009; 153: 54–60.
24. Ren Q, Sun RR, Zhao XF, Wang JX*. A selenium-dependent glutathione peroxidase (Se-GPx) and two glutathione S-transferases (GSTs) from Fenneropenaeus chinensis, Chinese shrimp. Comp Biochem Physiol. C. Comp Biochem Physiol C Toxicol Pharmacol. 2009 May; 149(4):613-23.
23. Tian YY, Liu Y, Zhao XF*, Wang JX*. Characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Dev. Comp. Immunol. 2009; 33: 772-779.
22. Ren Q, Zhao XF, Wang JX*. Molecular characterization and expression analysis of a chicken-type lysozyme gene from housefly Musca domestica. J Genet Genomics 2009; 36: 7-16.
21. Wang S, Zhao XF, Wang JX*. Molecular cloning and characterization of the translationally controlled tumor protein from Fenneropenaeus chinensis. Mol Biol Rep. 2009 Sep;36(7):1683-93. Epub 2008 Oct 14.
20. Zhao XF, Wang JX*. The antimicrobial peptides of shrimp immune response. Invertebrate Survival Journal 2008; 5: 162-179.
19. Jia YP Yu, Sun YD, Wang ZH, Wang Q, Wang XW, Zhao XF, Wang JX*. A single whey acidic protein domain (SWD)-containing peptide from fleshy prawn with antimicrobial and proteinase inhibitory activities. Aquaculture 2008; 284:246-259.
18. Shi XZ, Zhao XF, Wang JX*. Molecular cloning and expression analysis of chymotrypsin-like serine protease from the Chinese shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol. 2008; 25 589-597.
17. Bu XJ, Du XJ, Zhou WJ, Zhao XF, Wang JX*. Molecular cloning, recombinant expression, and characterization of lysozyme from Chinese shrimp Fenneropenaeus chinensis. Chinese J. Biotechnol., 2008; 24:723-732.
16. Ren Qian, Zhang Wei, Zhao Xiao-Fan, Wang Jin-Xing*. Gene cloning and expression analysis of ubiquitin derived from Musca domestica. Arch Insect Biochem Physiol. 2008; 68(2):89-99.
15. Shi XZ, Zhao X-F, and Wang J-X*. Molecular Cloning and Analysis of Function of Nucleoside Diphosphate Kinase (NDPK) from the Scallop Chlamys farreri. Biochemistry (Moscow), 2008; 73:686-692.
14. Sun YD, Fu LD, Jia YP, Du XJ, Wang Q, Wang YH, Zhao XF, Yu XQ, Wang JX*. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity. Mol Immunol. 2008; 45(2):348-361.
13. Chai LQ, Tian YY, Wang JX*, Zhao XF*. Molecular cloning and expression analysis of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Dev Comp Immunol. 2008;32(1):71-83.
12. Wang JX*, Zhao XF, Liang YL, Li L, Zhang W, Ren Q, Wang LC, Wang LY. Molecular characterization and expression of the antimicrobial peptide defensin from the housefly (Musca domestica). Cell Mol. Life Sci. 2006; 63(24):3072-3082.
11. Kang CJ, Xue JF, Liu N, Zhao XF, Wang JX*. Characterization and expression of a new subfamily member of penaeidin antimicrobial peptides (penaeidin 5) from Fenneropenaeus chinensis. Mol. Immunol. 2007; 44(7):1535-1543.
10. Du XJ, Zhao XF, Wang JX*. Molecular cloning and characterization of a lipopolysaccharide and beta-1,3-glucan binding protein from fleshy prawn (Fenneropenaeus chinensis).Mol Immunol. 2007; 44: 1085-1094.
9. Liang YL, Wang JX*, Zhao XF, Du XJ, Xue JF. Molecular cloning and characterization of cecropin from the housefly (Musca domestica), and its expression in Escherichia coli.Dev Comp Immunol. 2006; 30: 249-257.
8. Sun YD, Zhao XF, Kang CJ, Wang JX*. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fenneropenaeus chinensis. Mol Immunol. 2006; 43: 1202-1210.
7. Du XJ, Wang JX*, Liu N, Zhao XF, Li FH, Xiang JH. Identification and molecular characterization of a peritrophin-like protein from fleshy prawn (Fenneropenaeus chinensis). Mol Immunol. 2006; 43: 1633-1644.
6. Li DX, Du XJ, Zhao XF, Wang JX*. Cloning and expression analysis of an o-methyltransferase (OMT) gene from Chinese shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol. 2006; 21(3):284-292.
5. Li L, Wang JX*, Zhao XF, Kang CJ, Liu N, et al. High level expression, purification, and characterization of the shrimp antimicrobial peptide, Ch-penaeidin, in Pichia pastoris. Protein Expr Purif. 2005; 39 (2):144-151.
4. Wang JX*, Zhao XF. Progress in pattern recognition receptors of innate immunity in invertebrate. Prog. Biochem. Biophys. 2004; 31: 112-117.
3. Kang CJ, Wang JX*, Zhao XF, Yang XM, Shao HL, Xiang JH. Molecular cloning and expression analysis of Ch-penaeidin, an antimicrobial peptide from Chinese shrimp, Fenneropenaeus chinese. Fish Shellfish Immunol. 2004; 16:513-525.
2. Wang J-X*, Zhao XF, Deng Y, Qi HY, Wang ZJ. Chromosomal polymorphism of mandarin vole, Microtus mandarinus (Rodentia). Hereditas. 2003;138(1):47-53.
1. Wang JX*, Zhao XF, Koh HS, Deng Y, Qi HY. Chromosomal polymorphisms due to heterochromatin growth and pericentric inversions in white-bellied rat, Niviventer confucianus, from China. Hereditas. 2003;138(1):59-64.
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