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山东理工大学生命科学学院导师：朱海亮正文
朱海亮，男，教授，博士生导师，。
1965年3月出生于安徽省阜阳市。
zhuhl@nju.edu.cn；18913938847
一、简历
1988年兰州大学化学系获硕士学位；
1988-1994 年宁夏大学化学系讲师；
1998年南京大学化学化工学院获博士学位；
2000年中山大学化学与化学工程学院博士后，副研究员；
2000-2001德国 Philipps-University Marburg 化学系有机化学研究所二站博士后
2002-2011年武汉科技学院环境学院，南京大学生命科学学院，教授；
2011-，山东理工大学生命科学学院，南京大学生命科学学院，教授。
二、专业及方向：化学生物学、药物合成化学
三、主持的基金项目
主持973子课题、863子课题、国家支撑计划子课题、国家重大科技专项（河流主题）子课题、中央高校基本科研业务费专项资金创新团队、国家科技型中小企业技术创新基金、国家自然科学基金、湖北省创新团队、湖北省杰出青年基金等基金项目多项。指导的博士后在站期间获得中国博士后基金项目12项。
四、奖励和荣誉
（1）朱海亮、李环球、石磊、肖竹平、程魁、黄险峰、李玉广、由忠录、史大华，"市场药物及天然活性物质的结构改造、结构分析及其生物活性研究"，2008年度，教育部自然科学二等奖。
（2）朱海亮、陈悟、李玉广、由忠录，"天然活性物质的结构改造及其药物活性研究"，2009年度，湖北省自然科学三等奖。
（3）2009-，任Curr. Med. Chem.杂志Anti-CancerAgents in Medicinal Chemistry专栏副主编。
（4）2008入选中国科学院"百人计划"学者。
（5）2008-2011全国百篇优秀博士论文评审专家。
（6）2003湖北省 "有突出贡献的中青年专家"。
五、发表SCI收录论文400余篇，论文被SCI刊物引用2000余次。发表的部分论文目录如下（带星号*的为通讯作者）。
1．Xiang Lu, Hui Zhang, Xi Li, Guo Chen, Qing-Shan Li, Yin Luo, Ban-Feng Ruan, Xian-Wei Chen, Hai-Liang Zhu*, Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors, Bioorg. Med. Chem., 2011, 19, 6827-6832.
2．Kai Liu, Hai-Liang Zhu*, Nitroimidazoles as Anti-Tumor Agents, Anti-Cancer Agent Med. Chem., 2011, 11, 687-691.
3．Xiao-Min Zhang, Min Qiu, Juan Sun, Yan-Bin Zhang, Yu-Shun Yang, Xiao-Liang Wang, Jian-Feng Tang, Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents, Bioorg. Med. Chem., 2011, 19, 6518–6524.
4．You-Yi Xia, Hai-Liang Zhu*, Polyaniline nanofiber-reinforced conducting hydrogel with unique pH-sensitivity, Soft Matter, 2011, 7, 9388-9393.
5．Yin Luo, Yao Li, Ke-Ming Qiu, Xiang Lu, Jie Fu, Hai-Liang Zhu*, Metronidazole acid acyl sulfonamide: A novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors, Bioorg. Med. Chem. 2011, 19, 6069-6076.
6．Ya-Ping Hou, Juan Sun, Zhong-Hua Pang, Peng-Cheng Lv, Dong-Dong Li, Li Yan, Hong-Jia Zhang, Emily Xi Zheng, Jing Zhao, Hai-Liang Zhu*, Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors, Bioorg. Med. Chem. 2011, 19, 5948-5954.
7．Zhu-Ping Xiao, Tao-Wu Ma, Mei-Lin Liao, Yu-Ting Feng, Xiao-Chun Peng, Jia-Liang Li, Zhi-Ping Li, Ying Wu, Qun Luo, Yang Deng, Xiao Liang, Hai-Liang Zhu*, Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: Synthesis, molecular docking and structureeactivity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones, Eur. J. Med. Chem., 2011, 46, 4904-4914.
8．Juan Sun, Yu-Shun Yang, Wei Li, Yan-Bin Zhang, Xiao-Liang Wang, Jian-Feng Tang, Hai-Liang Zhu*, Synthesis, Biological Evaluation and Molecular Docking Studies of 1,3,4-Thiadiazole Derivatives Containing 1,4-Benzodioxan as Potential Antitumor Agents, Bioorg. Med. Chem. Lett., 2011, 21, 6116-6121.
9．Hong-Jia Zhang, Xuan Qin, Kai Liu, Di-Di Zhu, Xiao-Ming Wang, Hai-Liang Zhu*, Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino)phenyl-N0-phenyl-thiourea, Bioorg. Med. Chem. 2011, 19, 5708-5715.
10．Peng-Cheng Lv, Dong-Dong Li, Qing-Shan Li, Xiang Lu, Zhu-Ping Xiao, Hai-Liang Zhu*, Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents, Bioorg. Med. Chem. Lett. 2011, 21, 5374-5377.
11．Juan Sun, Ning Cao, Xiao-Min Zhang, Yu-Shun Yang, Yan-Bin Zhang, Xiao-Ming Wang, Hai-Liang Zhu*, Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells, Bioorg. Med. Chem. 2011, 19, 4895-4902.
12．Yin Luo, Ke-Ming Qiu, Xiang Lu, Kai Liu, Jie Fu, Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents, Bioorg. Med. Chem. 2011, 19, 4730-4738.
13．Dong-Dong Li, Peng-Cheng Lv, Hui Zhang, Hong-Jia Zhang, Ya-Ping Hou, Kai Liu, Yong-Hao Ye, Hai-Liang Zhu*, The combination of 4-anilinoquinazoline and cinnamic acid: A novel mode of binding to the epidermal growth factor receptor tyrosine kinase, Bioorg. Med. Chem. 2011, 19, 5012-5022.
14．Zhen-Wei Zhu, Lei Shi, Xiao-Ming Ruan, Ying Yang, Huan-Qiu Li, Suo-Ping Xu, Hai-Liang Zhu*, Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) trrosine kinase, J. Enzym. Inhibit. Med. Chem., 2011, 26(1), 37-45.
15．Zi-Lin Li, Qing-Shan Li, Hong-Jia Zhang, Yang Hu, Di-Di Zhu, Hai-Liang Zhu*, Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors, Bioorg. Med. Chem. 2011, 19, 4413-4420.
16．Hong-Jia Zhang, Di-Di Zhu, Zi-Lin Li, Juan Sun, Hai-Liang Zhu, Synthesis, molecular modeling and biological evaluation of b-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents, Bioorg. Med. Chem. 2011, 19, 4513-4519.
17．Xian-Feng Huang and Hai-Liang Zhu*, Resveratrol and Its Analogues: Promising Anticancer Agents, Curr. Med. Chem.-Anti-Can. Agents, 2011, 11, 479-490.
18．Jie Fu, Sheng Sheng, Teng Wen, Zhi-Ming Zhang, Qing Wang, Qiu-Xiang Hu, Qing-Shan Li, Shu-Qing An, Hai-Liang Zhu*, Polycyclic aromatic hydrocarbons in surface sediments of the Jialu River, Ecotoxicology, 2011, 20, 940-950.
19．Zhu-Ping Xiao, Hui Ouyang, Xu-Dong Wang, Peng-Cheng Lv, Ze-Jun Huang, She-Rong Yu, Tian-Fang Yi, Ye-Ling Yang, Hai-Liang Zhu*, 4-Alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation, Bioorg. Med. Chem. 2011, 19, 3884-3891.
20．Xin-Hua Liu, Ban-Feng Ruan, Jing-Xin Liu, Bao-An Song, Ling-Hong Jing, Jun Li, Yang Yang, Hai-Liang Zhu* and Xing-Bao Qi, Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents, Bioorg. Med. Chem. Lett., 2011, 21, 2916-2920.
21．Ban-Feng Ruan, Xiang Lu, Jian-Feng Tang, Yao Wei, Xiao-Liang Wang, Yan-Bin Zhang, Li-Sheng Wang and Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents, Bioorg. Med. Chem. 2011, 19, 2688-2695.
22．Jie Fu, Yan-Hua Ding, Luo Li, Sheng Sheng, Teng Wen, Lu-Ji Yu, Wu Chen, Shu-Qing An* and Hai-Liang Zhu*, Polycyclic aromatic hydrocarbons and ecotoxicological characterization of sediments from the Huaihe River, China, J. Environ. Monit., 2011, 13, 597-604.
23．Zhu-Ping Xiao, Xing-Bing He, Zhij-Yun Peng, tao-Ju Xiong, Juan Peng, Li-Hua Chen and Hai-Liang Zhu*, Synthesis, structure, molecular docking, and structure–activity relationship analysis of enamines: 3-Aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials, Bioorg. Med. Chem. 2011, 19, 1571-1579.
24．Z.-P. Xiao, Z.-Y. Peng, M.-J. Peng, W.-B. Yan, Y.-Z. Ouyang and Hai-Liang Zhu*, Flavonoids Health Benefits and Their Molecular Mechanism, Mini-Rev. Med. Chem., 2011, 11, 169-177.
25．Ban-Feng Ruan, Yu-Peng Tian, Ren-Tao Hu, Hong-Ping Zhou, Jie-Ying Wu, Jia-Xiang Yang and Hai-Liang Zhu*, Synthesis, crystal structures and in vitro antibacterial activity of two novel organotin(IV) complexes, Inorg. Chim. Acta, 2011, 365, 473-479.
26．Ban-Feng Ruan, Yu-Peng Tian, Hong-Ping Zhou, JieYing Wu, Ren-Tao Hu, Chen-Hao Zhu, Jia-Xiang Yang and Hai-Liang Zhu*, Synthesis, characterization and in vitro antitumor activity of three organotin(IV) complexes with carbazole ligand, Inorg. Chim. Acta, 2011, 365, 302-308.
27．Lei Shi, Zi-Lin Li, Ying Yang, Zhen-Wei Zhu, Hai-Liang Zhu*, Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors, Bioorg. Med. Chem. Lett., 2011, 21, 121-124.
28．Peng-Cheng Lv, Tian-Tian Cai, Yong Qian, Juan Sun, Hai-Liang Zhu*, Synthesis, biological evaluation of chrysin derivatives as potential immunosuppressive agents, Eur. J. Med. Chem., 2011, 46, 393-398.
29．Peng-Cheng Lv, Jing Xiong, Jin Chen, Kai-Rui Wang, Wen-Jun Mao and Hai-Liang Zhu*, Novel depsides as potential anti-inflammatory agents with potent inhibitory activity against Escherichia coli-induced interleukin-8 production, J. Enzym. Inhibit. Med. Chem., 2010, 25(4), 590-595.
30．Yong-Ming Cui, Wen-xuan Yan, Ying-Jie Cai, Wu Chen and Hai-Liang Zhu*, Synthesis, molecular docking, and inhibitory activity of a Ni Schiff-base complex against urease, J. Coord. Chem., 2010, 63(21), 3706-3713.
31．Jie Fu, Ying Yang, Xue-Wei Zhang, Wen-Jun Mao, Zhi-Ming Zhang, Hai-Liang Zhu*, Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase, Bioorg. Med. Chem. 2010, 18, 8457–8462.
32．Yong Qian, Hong-Jia Zhang, Peng-Cheng Lv, Hai-Liang Zhu*, Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents, Bioorg. Med. Chem. 2010, 18, 8218-8225.
33．Qing-Zhong Zheng, Xiao-Min Zhang, Ying Xu, Kui Cheng, Qing-Cai Jiao, Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents, Bioorg. Med. Chem. 2010, 18, 7836-7841.
34．Ying Yang, Lei Shi, Yang Zhou, Huan-Qiu Li, Zhen-Wei Zhu, Hai-Liang Zhu*, Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, 6653-6656.
35．Zhu-Ping Xiao*, Tao-Wu Ma, Wei-Chang Fu, Xiao-Chun Peng, Ai-Hua Zhang, Hai-Liang Zhu*, The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors, Eur. J. Med. Chem., 2010, 45, 5064-5070.
36．Huan-Qiu Li, Peng-Cheng Lv, Lei Shi and Hai-Liang Zhu*, Structure-based Discovery of Novel Antibacterials, Curr. Med. Chem.- Anti-Infective Agents, 2010, 9, 168-179.
37．Ban-Feng Ruan, Ten-Tao Hu, Yu-Peng Tian*, Jie-Ying Wu, Hai-Liang Zhu*, Synthesis, characterization, and biological activity of a Cu(I) complex with 2-(9H-carbazol-9-yl) acetic acid, J. Coord. Chem. 2010, 63(17), 2999-3005.
38．Suo-Ping Xu, Lei Shi, Yuan Pei, Ying Yang, Hai-Liang Zhu*, Synthesis and antibacterial activities of copper(II) with, [(2-hydroxy-3,5-diiodo-benzylidene)-amino]-acetic acid, J. Coord. Chem. 2010, 63(19), 3463-3470.
39．Xin-Hua Liu, Hui-Feng Liu, Jin Chen, Yang Yang, Bao-An Song, Lin-Shan Bai, Jing-Xin Liu, Hai-Liang Zhu*, Xing-Bao Qi, Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents, Bioorg. Med. Chem. Lett. 2010, 20, 5705-5708.
40．Wu Chen, Yuguang Li, Yongming Cui, Xian Zhang, Hai-Liang Zhu*, Qingfu Zeng*, Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors, Eur. J. Med. Chem., 2010, 45, 4473-4478.
41．Suo-Ping Xu, Hai-Liang Zhu*, Synthesis and antimicrobial activities of metal(II) complexes with 2,4-diiodo-6-phenyliminomethyl-phenol, J. Coord. Chem. 2010, 63(18), 3291-3300.
42．Lei Shi, Rui-Qin Fang, Zhen-Wei Zhu, Ying Yang, Kui Cheng, Wei-Qing Zhong, Hai-Liang Zhu*, Design and synthesis of potent inhibitors of b-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents, Eur. J. Med. Chem., 2010, 45, 4358-4364.
43．Peng-Cheng Lv, Juan Sun, Yin Luo, Ying Yang, Hai-Liang Zhu*, Design, synthesis, and structure–activity relationships of pyrazole derivatives as potential FabH inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, 4657-4660.
44．Yong Qian, Hong-Jia Zhang, Hao Zhang, Chen Xu, Jing Zhao, Hai-Liang Zhu*, Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents, Bioorg. Med. Chem. 2010, 18, 4991-4996.
45．Huan-Qiu Li, Yin Luo, Ran Song, Zi-Lin Li, Tao Yan, Hai-Liang Zhu*, Design, Synthesis, and Immunosuppressive Activity of New Deoxybenzoin Derivatives, ChemMedChem, 2010, 5(7), 1117-1122.
46．Yin Luo, Huan-Qiu Li, Yang Zhou, Zi-Lin Li, Hai-Liang Zhu*, Metronidazole-Deoxybenzoin Derivatives as Anti-Helicobacter pylori Agents with Potent Inhibitory Activity against HPE Induced Interleukin-8, ChemMedChem, 2010, 5(7), 1110-1116.
47．Yong Qian, Gao-Yuan Ma, A Lv, Hai-Liang Zhu, Jing Zhao and VH Rawal, Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines, Chem. Commun., 2010, 46(17), 3004-6.
48．Xin-Hua Liu, Hui-Feng Liu, Xu Shen, Bao-An Song, Pinaki S. Bhadury, Hai-Liang Zhu*, Jin-Xing Liu, Xing-Bao Qi, Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents, Bioorg. Med. Chem. Lett., 2010, 20, 4163-4167.
49．Peng-Cheng Lv, Huan-Qiu Li, Juan Sun, Yang Zhou, Hai-Liang Zhu*, Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents, Bioorg. Med. Chem. 2010, 18, 4606-4614.
50．Yong Qian, Gao-Yuan Ma, Ying Yang, Kui Cheng, Qing-Zhong Zheng, Wen-Jun Mao, Lei Shi, Jing Zhao*, Hai-Liang Zhu*, Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents, Bioorg. Med. Chem. 2010, 18, 4310-4316.
51．Jie Fu, Teng Wen, Qing Wang, Xue-Wei Zhang, Qing-Fu Zeng*, Shu-Qing An* and Hai-Liang Zhu*, Degradation of Active Brilliant Red X-3B by a microwave discharge electrodeless lamp in the presence of activated carbon, Environ. Technol., 2010, 31(7), 771-779.
52．Qing-Zhong Zheng, Kui Cheng, Xiao-Min Zhang, Kai Liu, Qing-Cai Jiao*, Hai-Liang Zhu*, Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents, Eur. J. Med. Chem., 2010, 45, 3207-3212.
53．Yong-Miao Shen, Peng-Cheng Lv, Wu Chen, Peng-Gang Liu, Ming-Zhu Zhang, Hai-Liang Zhu*, Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line, Eur. J. Med. Chem., 2010, 45, 3184-3190.
54．Jie Fu, Kui Cheng, Zhi-Ming Zhang, Rui-Qin Fang, Hai-Liang Zhu*, Synthesis, structure and structure–activity relationship analysis of caffeic acid amides as potential antimicrobials, Eur. J. Med. Chem., 2010, 45, 2638-2643.
55．Kui Cheng, Qing-Zhong Zheng, Jin Hou, Yang Zhou, Chang-Hong Liu*, Jing Zhao*, Hai-Liang Zhu*, Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics, Bioorg. Med. Chem. 2010, 18, 2447-2455.
56．Huan-Qiu Li, Yin Luo, Peng-Cheng Lv, Lei Shi, Chang-Hong Liu *, Hai-Liang Zhu*, Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents, Bioorg. Med. Chem. Lett. 2010, 20, 2025-2028.
57．Lei Shi, Ying Yang, Zi-Lin Li, Zhen-Wei Zhu, Chang-Hong Liu*, Hai-Liang Zhu*, Design of novel nicotinamides as potent and selective monoamine oxidase inhibitors, Bioorg. Med. Chem. 2010, 18, 1659-1664.
58．Peng-Cheng Lv, Kai-Rui Wang, Qing-Shan Li, Jin Chen, Juan Sun, Hai-Liang Zhu*, Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents, Bioorg. Med. Chem. 2010, 18, 1117-1123.
59．Qing-Zhong Zheng, Fei Zhang, Kui Cheng, Ying Yang, Yu Chen, Yong Qian, Hong-Juan Zhang, Huan-Qiu Li, Chang-Fang Zhou, Shu-Qing An*, Qing-Cai Jiao*, Hai-Liang Zhu*, Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents, Bioorg. Med. Chem. 2010, 18, 880-886.
60．Peng-Cheng Lv, Chang-Fang Zhou, Jin Chen, Peng-Gang Liu, Kai-Rui Wang, Wen-Jun Mao, Huan-Qiu Li, Ying Yang, Jing Xiong, Hai-Liang Zhu*, Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorg. Med. Chem. 2010, 18, 314-319.
61．Huan-Qiu Li, Tao Yan, Ying Yang, Lei Shi, Chang-Fang Zhou*, Hai-Liang Zhu*, Synthesis and structure–activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N0-phenylureas and thioureas as antitumor agents. Bioorg. Med. Chem. 2010, 18, 305-313.
六、部分发明专利
1、 朱海亮、李冬冬、王晓亮、李静然、孙建、杜茜如、方飞，4-苯胺喹唑啉类和取代肉桂酸的复合物及其制备方法与用途，申请号：201110315166.9
2、 朱海亮、孙娟、张雁滨、杨雨顺、王晓亮、张飞，一类噻唑琳酮衍生物及其制法，申请号：201110308986.5
3、 朱海亮、王晓亮、张雁滨、杨雨顺、汤剑锋、张飞，香草酸酰腙类衍生物及其制备和用途，申请号：201110309009.7
4、 朱海亮、胡杨、张雁滨、王晓亮、杨雨顺，1,3,4-噁二唑类化合物的制备及其在抗癌治疗药物中的应用，申请号：201110308980.8
5、 朱海亮、骆银、裘科明。肉桂酰磺酰胺类化合物的制备及其在抗癌治疗中的应用。申请号：201110170735.5。
6、 朱海亮、付杰、张雪薇、杨先辉、张莉蓉、刘常宏、张平、宋双。新型藻类隔开培养装置。申请号：2011050900142460。
7、 朱海亮、张志明、张雪薇、燕茹。2,5-二取代-1,3,4-噁二唑衍生物及其制法与用途。申请号：201110087058.0。
8、 朱海亮、付杰、杨先辉、张雪薇、张莉蓉、何祯祥。光皮树油在减肥药物开发中的应用，申请号201110063909.8。
9、 朱海亮、张晓敏、孙娟、刘凯、杨雨顺、燕茹、张雁滨，含1,4-苯并二噁烷的1,3,4-噁二唑衍生物的制法及其在抗癌药物中应用，申请号201110073034.X
10、 朱海亮、付杰、张莉蓉、张雪薇、杨先辉、何祯祥，光皮树油在降血脂药物中的应用，申请号201110063909.8。
11、 朱海亮、孙娟、杨雨顺、张晓敏、章虹佳、刘凯、李子琳 秦旋,含1,4-苯并二噁烷的噻二唑衍生物及其制法与其抗菌活性，申请号201110063740.6。
12、 朱海亮、章虹佳、祝迪迪、孙娟、李子琳，塞克硝唑肉桂酸酯衍生物的合成及其在抗菌药物方面的应用，申请号201110063758.6。
13、 朱海亮、郑庆忠、张晓敏、董凯、焦庆才。2-氯吡啶衍生物及其制法与在制备抗肝癌药物中的应用，申请号：201010244869.2，公开号：CN 101914095A。
14、 朱海亮、郑庆忠、刘凯、董凯、焦庆才。1,3,4-噁二唑衍生物及其制法与在制备抗肿瘤药物中的应用，申请号：201010240482.X，公开号：CN 101914094A。
15、 朱海亮、付杰、张志明。苯并三唑衍生物及其制法与用途，申请号 201010222902.1，申请日：2010.07.09，公开日：2010.12.29，公开号CN 101928254A。
16、 朱海亮、吕鹏程、王开锐、陈进。一类含有吡唑环的硫脲类衍生物及其制法和用途，申请号：200910263121.4，公开号：CN 101735150
17、 朱海亮、骆银、李环球。苯并三唑衍生物及其制法与用途，申请号201010222902.1
18、 朱海亮、骆银、李环球。一种肟类化合物及其制备方法与用途，申请号200910233389.3
19、 朱海亮、郑庆忠、程魁、焦庆才。苯甲酸氮芥衍生物及其制备方法与用途，申请号200910036290.4
20、 朱海亮、吕鹏程、王开锐、陈进、毛文君。一类白杨素和取代水杨酸酯复合物及其制法和用途，申请号：201010111304.7，公开号：CN 101768147
21、 朱海亮、王开锐、吕鹏程。白杨素长链衍生物及其制备方法与用途，申请号：201010111246.8，公开号：CN 101774994A
22、 朱海亮、肖竹平、钱勇。3-芳基喹啉类化合物及其制法和用途，申请号：201010111249.1，公开号：CN 101759635
23、 朱海亮、吕鹏程、阮班锋、孙娟、陈进。一类含有吡唑环的噻唑类衍生物及其制法和用途，申请号：200910264116.5，公开号：CN 101759695，授权号ZL200910264116.5。
24、 朱海亮、吕鹏程、王开锐、陈进。一类含有吡唑环的硫脲类衍生物及其制法和用途，申请号：200910263221.4.
25、 朱海亮、李青山、李环球、严涛、骆银。一类尿素衍生物及其制法与用途，申请号：200910262954.9，公开号：CN 101735113.
26、 朱海亮，祝祯伟，石磊，杨莹 水杨酰苯胺类衍生物及其制法与用途。专利申请号200910233731.X
27、 朱海亮、杨莹、石磊、祝祯伟。N-喹啉酰胺类衍生物及其制法与用途，申请号：200910232198.5，公开号：CN101723894.
28、 朱海亮、吕鹏程。一类新型白杨素和取代水杨酸酯复合物及其制法和用途，申请号：200910184606.4.
29、 朱海亮、毛文君、吕鹏程。甲硝唑和取代水杨酸的复合物及其制法与用途，申请号：200910027775.7. 公开号CN 101560189A；授权号ZL200910027775.7.
30、 朱海亮、李环球、严涛。一类硫脲类衍生物及其制备方法与用途，申请号：200910031329.3. 公开号CN 101560175A
31、 朱海亮，宋忠诚，马高远，吕鹏程，石磊。一类新型N-叔丁基化噻唑烷酸类化合物及其制法和用途. 申请号：200810234101.X。公开号：CN101407502。授权号：ZL 2008 10234101.X。
32、 朱海亮，吕鹏程，宋忠诚。一类新型缩酚酸类化合物及其制法和用途。申请号：200810020994.8。公开号：CN101333166。
33、 朱海亮、石磊、宋忠诚，1,4-丁二磺酸钠的制备方法，申请号2007101918947，公开号CN 101219976A，授权号ZL200710191894.7.
34、 朱海亮，李环球，石磊，曹平，尿素类衍生物及其制备方法与用途，申请号200710190629.7，公开号CN101161645A，授权号ZL200710190629.7.
35、 朱海亮，肖竹平，张丽娜，徐 琛，喹啉类鸢尾黄素电子等排体及其制法和用途，申请号 2006101613662，公开号 CN100999492A，授权号ZL200610161366.2.
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