宁波大学医学院导师：徐淑君

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宁波大学医学院导师：徐淑君正文

[导师姓名]
徐淑君

[所属院校]
宁波大学

[基本信息]
导师姓名：徐淑君
性别：女
人气指数：3334
所属院校：宁波大学
所属院系：医学院
职称：副教授
导师类型：
招生专业：生物化学与分子生物学
研究领域：神经生物

[通讯方式]
办公电话：0574-87609594
电子邮件：xushujun@nbu.edu.cn
通讯地址：宁波江北风华路818号宁波大学医学院王长来楼409

[个人简述]
徐淑君，女，博士，宁波大学医学院行为神经科学研究中心副教授，斯坦福医学院分子和细胞生理系访问学者。浙江省神经科学学会理事，浙江省神经科学学会细胞和分子生物学委员会副主任委员，美国神经科学学会（SocietyofNeuroscience），中国神经科学学会，中国生理科学会会员。近年来一直从事神经科学方面的研究。相关研究成果获得省市等各类科研成果奖6项，发表论文23篇，其中SCI收录论文20篇，包括Molecular Neurobiology(IF: 6.19), hippocampus(IF: 5.17)、Journal of Alzheimers Disease(IF: 3.61)、Neuroscience(IF: 3.38)等杂志。文章总被引用次数达100多次。发表的论文被Trends in Neurosciences（影响因子为13.3）、Progress in Lipid Research（影响因子为9.5）、Neurobiology of Disease（影响因子为5.1）等国际著名期刊上的文章引用。曾担任Journal of Alzheimers disease编委，是该杂志、Molecular Neurobiology、Neuroscience Bulletin、Progress in Biochemistry and Biophysics等杂志的审稿人。先后主持国家自然科学基金一项(30900430)，浙江省自然科学基金两项(LY12H09001，LY16H09001)，市自然科学基金三项(2011A610065, 2009A610119，2014A610258)，浙江省教育厅项目一项(Y200803366)、市人才项目一项（领军和拔尖人才）。主要获奖情况：
[1]浙江省科技论文二等奖：Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in culturedhippocampal neurons. 排名第一。
[2]宁波大学青年学术创新三等奖：神经退行性疾病发病机制的研究。排名第一。
[3]宁波市自然科学优秀论文奖：海马神经元突触囊泡数目的多少和释放模式。排名第一。
[4]浙江省科技进步二等奖：阿尔茨海默氏症中β淀粉样蛋白调节突出可塑性的机制研究。排名第三。
[5]宁波市科技进步一等奖（2011）：老年痴呆症的病理机制及治疗技术研究。排名第四。
联系电话：0574-87609594, 15888592742. 邮箱： xushujun@nbu.edu.cn。

[科研工作]
[1]Shujun Xu#, Guilan Liu, Xiaoming Bao, Jie Wu, Shaomin Li, Bangxu Zheng, Roger Anwyl, Qinwen Wang(2014). Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number.Journal ofAlzheimer’s Disease, 39(2):239-251. (#Corresponding author)
[2]Liting Jiang, Meng Huang,Shujun Xu#, Yu Wang, Pengyuan An, Chenxi Feng, Xiaowei Chen, Xiaofei Wei, Yifan Han, Qinwen Wang(2016). Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway.Molecular Neurobiology. 53:3832–3841(#Corresponding author)
[3]Shujun Xu, Qiao Guan, Chuang Wang,Xiaofei Wei, Xiaowei Chen,Junfang Zhang, Lan Chang,Wenhua Zhou, Istvan Mody,Qinwen Wang(2014).Rosiglitazone prevents the memory deficits induced by amyloid-beta oligomers via inhibition of inflammatory responses.Neuroscience Letters, 578(2014):7-11.
[4]Shujun Xu, Suya Zhou, Di Xia, Gang Chen, Shumin Duan, Jianhong Luo (2010).Defects of synaptic vesicle turnover at excitatory and inhibitory synapse in niemann-pick C1 deficient neurons.Neuroscience,167(2010): 608–620
[5]Suya Zhou, Shujun Xu*, Yinggang Yan, Huimei Yu, Shucai Ling, Jianhong Luo(2011).Decreased Purinergic Inhibition of Synaptic Activity in a Mouse Modelof Niemann-Pick Disease Type C. Hippocampus, 21(2011):212-219 (*Co-first author).
[6]Shujun Xu#,Xiaowei Chen, Xiaofei Wei, Guilan Liu, Qinwen Wang (2011). Presynaptic impairment in Niemann-Pick C1-deficient neurons: Not dependenton presence of glial cells. Neuroscience Letters,496(2011),54-59.(#Corresponding author)
[7]Bangxu Zheng, Pengyuan An, Liting Jiang, Yiyi Zheng, Qinwen Wang, Shujun Xu#(2015). Progress on the Mechanism of Intracellular Degradation ofβ-Amyloid Protein.Chinese Journal of Cell Biology, 37(5): 753–758. (#Corresponding author)
[8]LinLu, Shujun Xu#, Qinwen Wang(2012). The Relationship Between Astrocyte-mediated Metabolism ofβ-AmyloidProtein and Pathogenesis of the Early Stages of Alzheimer’s Disease.Progress in Biochemistry and Biophysics, 39(8): 715~720. (#Corresponding author)
[9]Guilan Liu, Xiaoming Bao, ZhouyiLu, Shujun Xu#, Qinwen Wang(2012).The Effect of Rosiglitazone on The DendriticDevelopment of Hippocampal Neurons.Progress in Biochemistry and Biophysics, 39(6): 574~580. (#Corresponding author)
[10]Shujun Xu,Guilan Liu (2011). Recent Progress of Mitochondrial Dysfunction Induced byβ-Amyloid Protein. Progress in Biochemistry and Biophysics, 37(6): 589~593.
[11]Shujun Xu, Ping Wang, Di Xia(2009). Quantitative analysis of synaptic vesicle release and readily releasablepool size in hippocampal neurons.Acta Physiologica Sinica, 61 (6): 505-510
[12]Shujun Xu,Wei Ning, Zhengping Xu, Suya Zhou, Huai Chiang, Jianhong Luo (2006).Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in culturedhippocampal neurons. Neuroscience Letters,398(2006),253-257.
[13]Shujun Xu, Zhong Chen, Lijun Zhu, Haiqing Shen, Jianhong Luo (2005).Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats. Acta Pharmacologia Sinica,26(2005),177-180.
[14]Wei Ning,Shujun Xu,Huai Chiang, Zhengping Xu, Suya Zhou, Jianhong Luo (2007). Effects of GSM 1800-MHz on dendritic development of hippocampal neurons in Culture. Acta Pharmacologia Sinica,28(2007),1873-1880.
[15]Lan Chang, Wei Cui,Yong Yang, Shujun Xu, Wenhua Zhou, Hongjun Fu,Shengquan Hu, Shinghung Mak, Juwei Hu, Qin Wang, VictorPui-YanMa, Tony Chung-lit Choi, Edmond Dik-lung Ma, Liang Tao, Yuanping Pang, Michael J. Rowan, Roger Anwyl, Yifan Han, Qinwen Wang(2015).Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Scientific Report,5(2015):10256.
[16]Xiaowei Chen,JuweiHu, Liting Jiang, Shujun Xu, Zhengping Xu, Chuang Wang, Junfang Zhang,Xiaofei Wei, Lan Chang, Qinwen Wang(2014).Brilliant Blue G improves cognition in an animal model of Alzheimer's disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons.Neuroscience,279(2014):94-101.
[17]Lan Chang, Fushun Li, Xiaowei Chen, Shujun Xu,Chuang Wang, Hongzhuan Chen, Qinwen Wang(2014).Effects of acidic oligosaccharide sugar chain on amyloid oligomer-induced impairment of synaptic plasticity in rats.MetabolicBrain Disease,29(3):683-690.
[18]Yinggang Yan, Jie Zhang, Shujun Xu,Jianhong Luo, Shuang Qiu, Wei Wang(2014). Clustering of surface NMDA receptors is mainly mediated by theC-terminus of GluN2A in cultured rat hippocampal neurons.Neuroscience Bulletin,30(4): 655–666.
[19]Xiaowei Chen,Ruyi Lin, Lan Chang, Shujun Xu,, Xiaofei Wei, Junfang Zhang,Chuang Wang, Roger Anwyl, Qinwen Wang(2013).Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3.Neuroscience,253(2013):435-43
[20]Xiaofei Wei,Yanghui Zhang, Lulu Zhang, Shujun Xu, Xiaowei Chen, Chuang Wang,Qianjun Si, Ketao Ma, Qinwen Wang(2013). CCK-8S increases the firing frequency of CCK-positive neurons and facilitates excitatory synaptic transmission in primary rat hippocampal neurons.Neuroscience Letters, 549(2013):34-39.
[21]Lulu Zhang,Xiaofei Wei,Yanghui Zhang,Shujun Xu, Xiaowei Chen, Chuang Wang,Qinwen Wang(2013). CCK-8S increased the filopodia and spines density in cultured hippocampal neurons of APP/PS1 and wild-type mice.Neuroscience Letters,542(2013):47-52.
[22]Fushun Li,Xiaowei Chen, Feiming Wang, Shujun Xu,Lan Chang, Roger Anwyl, Qinwen Wang(2013).Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption.Neural Regenernation Research,8(1):49-55.
[23]Lijun Jun, Zhong Chen, Lishan Zhang, Shujun Xu,Ajing Xu, Jianhong Luo(2004).Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures. Neuroscience Letters,356(2004):53-56.
浙江省神经科学学会理事，浙江省神经科学学会细胞和分子生物学委员会副主任委员
主持国家自然科学基金项目“NPC1蛋白突变对突触形成和突触功能的影响及其机制研究”, 浙江省自然科学基金项目“胶质细胞溶酶体介导的阿尔茨海默病发病机制研究”及“钙敏感受体在阿尔茨海默病中的作用及其机制研究”，宁波市自然科学基金项目“罗格列酮对阿尔茨海默病突触功能损伤的保护作用及其机制研究”, 浙江省教育厅项目项目“β淀粉样蛋白释放机制的研究”，宁波市领军和创新人才项目等

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