南方医科大学南方医院导师:马欣
[通讯方式]
电子邮件:maxinfly@126.com
[个人简述]
本人主要从事麻醉药物对炎症相关疾病的影响和机制研究。异丙酚作为一种快速短效静脉麻醉药被广泛地应用于临床各种手术麻醉的诱导和维持,然而除了其作为麻醉药的特殊优点,异丙酚还具有很多的非麻醉效应,其中引起注意的是异丙酚具有非常重要的抗炎和器官保护作用,因此探讨异丙酚的抗炎作用并阐明其相关机制具有重要科学意义。本人研究方向旨在为深入阐述异丙酚的抗炎作用拓展新思路。
[科研工作]
1. Ma X, Zhao JY, Zhao ZL, Ye J, Li SF, Fang HH, Gu MN, Hu YW, Qin ZS. Propofol Attenuates Lipopoly- saccharide-Induced Monocyte Chemoattractant Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells. Inflammation. 201538(3):1329-36. (IF:1.921)2.Ma X, Li SF, Qin ZS, Ye J, Zhao ZL, Fang HH, Yao ZW, Gu MN, Hu YW. Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγLXRα signaling pathway in THP-1 macrophage- derived foam cells. Cardiovasc Pathol. 2015 Jul-Aug24(4):230-5. (IF:2.336)3. Ma X, Hu YW, Zhao ZL, Zheng L, Qiu YR, Huang JL, Wu XJ, Mao XR, Yang J, Zhao JY, Li SF, Gu MN, Wang Q. Anti-inflammatory effects of propofol are mediated by apolipoprotein M in a hepatocyte nuclear factor-1α-dependent manner. Arch Biochem Biophys. 2013 533(1-2):1-10. (IF: 3.043)4. Ma X, Hu YW, Mo ZC, Li XX, Liu XH, Xiao J, Yin WD, Liao DF, Tang CK. NO-1886 up-regulates Niemann-Pick C1 protein (NPC1) expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells. Cardiovasc Drugs Ther. 2009 23(3): 199-206. (IF: 2.952)5. Hu YW, Yang JY, Ma X(equal contribution), Chen ZP, Hu YR, Zhao JY, Li SF, Qiu YR, Lu JB, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q. A lincRNA- DYNLRB2-2GPR119GLP-1RABCA1-dependent Signal Transduction Path-way Is Essential for the Regulation of Cholesterol Homeostasis and Inflammatory Reactions. J Lipid Res. 2014 55(4): 681-697. (SCI收录, IF: 4.730)6. Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q. VNN1 Promotes Atherosclerosis Progression in apoE Deficiency Mice Fed a High Fat High Cholesterol Diet. J Lipid Res. 2016 57(8):1398-411.(IF: 4.368)
[教育背景]
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